Search Results
Overview
| Uniprot ID | Q4G0N4 |
|---|---|
| Protein Name | NAD kinase 2, mitochondrial |
| Gene Name | NADK2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | LKQLLALKGSSYSGL |
| 120 | ERHHIHTKNVEHIID |
| 302 | VDDGPWEKQKSSGLN |
| 304 | DGPWEKQKSSGLNLC |
| 339 | EDVLNIAKRQGNLSL |
| 397 | RQRCFSSKVCVRSRC |
| 76 | SRVVVVAKTTRYEFE |
Function
Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo
Protein Sequence
10
MTCYRGFLLG
20
SCCRVAGGRA
30
AALRGPGAGG
40
PAARPRLGGD
50
GGGRRHLGQG
60
QPRELAGCGS
70
RADGGFRPSR
80
VVVVAKTTRY
90
EFEQQRYRYA
100
ELSEEDLKQL
110
LALKGSSYSG
120
LLERHHIHTK
130
NVEHIIDSLR
140
NEGIEVRLVK
150
RREYDEETVR
160
WADAVIAAGG
170
DGTMLLAASK
180
VLDRLKPVIG
190
VNTDPERSEG
200
HLCLPVRYTH
210
SFPEALQKFY
220
RGEFRWLWRQ
230
RIRLYLEGTG
240
INPVPVDLHE
250
QQLSLNQHNR
260
ALNIERAHDE
270
RSEASGPQLL
280
PVRALNEVFI
290
GESLSSRASY
300
YEISVDDGPW
310
EKQKSSGLNL
320
CTGTGSKAWS
330
FNINRVATQA
340
VEDVLNIAKR
350
QGNLSLPLNR
360
ELVEKVTNEY
370
NESLLYSPEE
380
PKILFSIREP
390
IANRVFSSSR
400
QRCFSSKVCV
410
RSRCWDACMV
420
VDGGTSFEFN
430
DGAIASMMIN
440
KEDELRTVLL
EQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0003951 | NAD+ kinase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0019674 | NAD+ metabolic process |
| Biological Process | GO:0006741 | NADP+ biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.