Overview
| Uniprot ID | Q4GWZ2 |
|---|
| Protein Name | Small ribosomal subunit protein uS2 |
|---|
| Gene Name | RPSA |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 220 |
EEQAAAEKAVTKEEF |
| 42 |
EQYIYKRKSDGIYII |
| 52 |
GIYIINLKRTWEKLL |
| 57 |
NLKRTWEKLLLAARA |
| 89 |
TGQRAVLKFAAATGA |
Function
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA
Protein Sequence
10
MSGALDVLQM
20
KEEDVLKFLA
30
AGTHLGGTNL
40
DFQMEQYIYK
50
RKSDGIYIIN
60
LKRTWEKLLL
70
AARAIVAIEN
80
PADVSVISSR
90
NTGQRAVLKF
100
AAATGATPIA
110
GRFTPGTFTN
120
QIQAAFREPR
130
LLVVTDPRAD
140
HQPLTEASYV
150
NLPTIALCNT
160
DSPLRYVDIA
170
IPCNNKGAHS
180
VGLMWWMLAR
190
EVLRMRGTIS
200
REHPWEVMPD
210
LYFYRDPEEI
220
EKEEQAAAEK
230
AVTKEEFQGE
240
WTAPAPEFTA
250
TQPEVADWSE
260
GVQVPSVPIQ
270
QFPTEDWSAQ
280
PTTEDWSAAP
290
TAQATEWVGT
TTEWS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0098556 |
cytoplasmic side of rough endoplasmic reticulum membrane |
| Cellular Component |
GO:0022627 |
cytosolic small ribosomal subunit |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0043236 |
laminin binding |
| Molecular Function |
GO:0005055 |
laminin receptor activity |
| Molecular Function |
GO:0003735 |
structural constituent of ribosome |
| Molecular Function |
GO:0001618 |
virus receptor activity |
| Biological Process |
GO:0002181 |
cytoplasmic translation |
| Biological Process |
GO:0000028 |
ribosomal small subunit assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.