Search Results
Overview
| Uniprot ID | Q4KLF8 |
|---|---|
| Protein Name | Actin-related protein 2/3 complex subunit 5 |
| Gene Name | Arpc5 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 13 | VSSARFRKVDVDEYD |
| 3 | *****MSKNTVSSAR |
| 67 | KNPPINTKSQAVKDR |
Function
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005885 | Arp2/3 protein complex |
| Cellular Component | GO:0030863 | cortical cytoskeleton |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0035861 | site of double-strand break |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Biological Process | GO:0051639 | actin filament network formation |
| Biological Process | GO:0034314 | Arp2/3 complex-mediated actin nucleation |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0097581 | lamellipodium organization |
| Biological Process | GO:0030011 | maintenance of cell polarity |
| Biological Process | GO:0061842 | microtubule organizing center localization |
| Biological Process | GO:0021769 | orbitofrontal cortex development |
| Biological Process | GO:0030833 | regulation of actin filament polymerization |
| Biological Process | GO:0014909 | smooth muscle cell migration |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.