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Overview

Uniprot IDQ4KLH4
Protein NameParaspeckle component 1
Gene NamePspc1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
14 LKQVRIEKNPARLRA
343 LRNQELQKRKQIQLR
518 GNFEGPNKRRRY***
8 MMLRGNLKQVRIEKN

Function

RNA-binding protein required for the formation of nuclear paraspeckles (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (By similarity). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity)

Protein Sequence

10 MMLRGNLKQV 20 RIEKNPARLR 30 ALESAAGESE 40 PVAAAAMALT 50 LAGEQPPPPA 60 PSEEHPDEEM 70 GFTIDIKSFL 80 KPGEKTYTQR 90 CRLFVGNLPT 100 DITEEDFKRL 110 FERYGEPSEV 120 FINRDRGFGF 130 IRLESRTLAE 140 IAKAELDGTI 150 LKSRPLRIRF 160 ATHGAALTVK 170 NLSPVVSNEL 180 LEQAFSQFGP 190 VEKAVVVVDD 200 RGRATGKGFV 210 EFAAKPPARK 220 ALERCGDGAF 230 LLTTTPRPVI 240 VEPMEQFDDE 250 DGLPEKLMQK 260 TQQYHKEREQ 270 PPRFAQPGTF 280 EFEYASRWKA 290 LDEMEKQQRE 300 QVDRNIREAK 310 EKLEAEMEAA 320 RHEHQLMLMR 330 QDLMRRQEEL 340 RRLEELRNQE 350 LQKRKQIQLR 360 HEEEHRRREE 370 EMIRHREQEE 380 LRRQQEGFKP 390 NYMENREQEM 400 RMGDMGPRGA 410 INMGDAFSPA 420 PAGTQGPPPM 430 MGMNMNNRGT 440 IPGPPMGPGP 450 AMGPEGAANM 460 GTPMIPDNGA 470 VHNDRFPQGP 480 PSQMGSPMGN 490 RTGSETPQAP 500 MSAVGPVSGG 510 PGGFGRGSQG 520 GNFEGPNKRR RY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0001650 fibrillar center
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0042382 paraspeckles
Cellular Component GO:0090575 RNA polymerase II transcription regulator complex
Molecular Function GO:0003723 RNA binding
Biological Process GO:0002218 activation of innate immune response
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045087 innate immune response
Biological Process GO:0140694 membraneless organelle assembly
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0042752 regulation of circadian rhythm
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0048511 rhythmic process

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.