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Overview

Uniprot ID	Q4KLJ3
Protein Name	Nucleolar GTP-binding protein 2
Gene Name	Gnl2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
659	VSDAAPTKRARKWNA
663	APTKRARKWNAQVEE
88	FGNTRVIKQASLQKF

Function

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels

Protein Sequence

10 MVKPKYKGRS 20 TINRSAASTN 30 PDRVQGAGGQ 40 NMRDRGTIRR 50 LNMYRQKERR 60 NSRGKVIKPL 70 QYQSTVAPGT 80 VARVEPNIKW 90 FGNTRVIKQA 100 SLQKFQEEMD 110 KVMKDPYKVV 120 MKQSKLPMSL 130 LHDRVQPHNA 140 KVHILDTESF 150 ESTFGPKSQR 160 KRPNLFASDM 170 QSLLENAEMS 180 TESYDQGKDR 190 DLVTEDTGVR 200 NEAQEEIYKK 210 GQSKRIWGEL 220 YKVIDSSDVV 230 VQVLDARDPM 240 GTRSSHIEAY 250 LKKEKPWKHL 260 IFVLNKCDLV 270 PTWATKRWVA 280 VLSKDYPTLA 290 FHASLTNPFG 300 KGAFIQLLRQ 310 FGKLHTDKKQ 320 ISVGFIGYPN 330 VGKSSVINTL 340 RSKKVCNVAP 350 IAGETKVWQY 360 ITLMRRIFLI 370 DCPGVVYPSE 380 DSETDIVLKG 390 VVQVEKIKAP 400 QDHIGAVLER 410 AKPEYISKTY 420 KIESWENAED 430 FLEKLALRTG 440 KLLKGGEPDL 450 LTVSKMVLND 460 WQRGRIPFFV 470 KPPNAEMPTT 480 PQLPPSSPLE 490 VTTETTQNNP 500 EEETIETEVE 510 RSDSVIEKEP 520 EAGCSQDENS 530 EMQQILARVR 540 QNFGKINVGP 550 QFSADDLVPV 560 DDLVPVDLSD 570 LEDLESSEEE 580 EEQEQEQPGE 590 DAEEECSRDT 600 RGGPVEDDTK 610 AVIRALDEKI 620 AKYQRFLNKA 630 KAKKFSAIRI 640 SKDLSEKVFA 650 KYEEEKKASA 660 EVSDAAPTKR 670 ARKWNAQVEE 680 EPSDKTQRML 690 TCKERRRAAR 700 QQQSKKVGVR 710 YYETHNVKNR 720 NRNKKKTNDS 730 EGQKHRHKKF RQKQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005730	nucleolus
Molecular Function	GO:0005525	GTP binding

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.