Search Results
Overview
| Uniprot ID | Q4KLJ8 |
|---|---|
| Protein Name | Phosducin-like protein 3 |
| Gene Name | Pdcl3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 218 | ENPKKAIKDVLLSSV |
| 84 | QQRLAEWKATQLRNK |
Function
Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (By similarity). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (PubMed:27496612). Modulates the activation of caspases during apoptosis (By similarity)
Protein Sequence
10
MQDPNADTEW
20
NDILRKKGIL
30
PPKESLKELE
40
EEEEGKEEQR
50
LQQSVVKTYE
60
DMTLEELQEN
70
EDEFSEEDER
80
AIEMYRQQRL
90
AEWKATQLRN
100
KFGEVLEISG
110
KDYVQEVTKA
120
GEGLWVVLHL
130
YKQGIPLCSL
140
INHHLSGLAR
150
KFPDVKFIKA
160
ISTTCIPNYP
170
DRNLPTVFVY
180
REGDIKAQFI
190
GPLVFGGMNL
200
TIDELEWKLS
210
ESGAIKTELE
220
ENPKKAIKDV
230
LLSSVRDPVP
240
MRRDSDSEDD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0097356 | perinucleolar compartment |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0043184 | vascular endothelial growth factor receptor 2 binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0034605 | cellular response to heat |
| Biological Process | GO:1903333 | negative regulation of protein folding |
| Biological Process | GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:0001938 | positive regulation of endothelial cell proliferation |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.