Overview
| Uniprot ID | Q4KLK7 |
|---|
| Protein Name | Nucleolar protein 56 |
|---|
| Gene Name | Nop56 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 559 |
ITPKKKRKFSEEPEA |
| 572 |
EAAASCTKSSTKKKK |
Function
Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs)
Protein Sequence
10
MVLLHVLFEH
20
AVGYALLALK
30
EVEEISLLLP
40
QVEECVLNLG
50
KFHNVVRLVA
60
FCPFSSSQVA
70
LENANAVSEG
80
VVHEDLRLLL
90
ETYLPSKKKK
100
VLLGVGDPKI
110
GAAIQEELGY
120
NCQTGGVIAE
130
ILRGVRLHFH
140
NLVKGLTDLS
150
ACKAQLGLGH
160
SYSRAKVKFN
170
VNRVDNMIIQ
180
SISLLDQLDK
190
DINTFSMRVR
200
EWYGYHFPEL
210
VKIINDNATY
220
CRLAQFIGNR
230
RELNEEKLEK
240
LEEITMDGAK
250
AKAILDASRS
260
SMGMDISAID
270
LINIESFSSR
280
VVSLSEYRQS
290
LHNYLRSKMS
300
QVAPSLSALI
310
GEAVGARLIA
320
HAGSLTNLAK
330
YPASTVQILG
340
AEKALFRALK
350
TRGNTPKYGL
360
IFHSTFIGRA
370
AAKNKGRISR
380
YLANKCSIAS
390
RIDCFSEVPT
400
SVFGEKLREQ
410
VEERLSFYET
420
GEIPRKNLDV
430
MKEAVVQAEE
440
AAAEITRKLE
450
KQEKKRLKKE
460
KKRLAALALA
470
SSENSSTPEE
480
CEEVNEKPKK
490
KKLKPQETLQ
500
ENGMEDPPVS
510
LPKTKKKKAF
520
PKEELASDLE
530
EMATSSISVP
540
KKKKSLPKEE
550
VASEPEEAAS
560
PITPKKKRKF
570
SEEPEAAASC
580
TKSSTKKKKK
SQKAREED
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031428 |
box C/D methylation guide snoRNP complex |
| Cellular Component |
GO:0001650 |
fibrillar center |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0070761 |
pre-snoRNP complex |
| Cellular Component |
GO:0032040 |
small-subunit processome |
| Cellular Component |
GO:0005732 |
sno(s)RNA-containing ribonucleoprotein complex |
| Molecular Function |
GO:1990226 |
histone methyltransferase binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0030515 |
snoRNA binding |
| Biological Process |
GO:0042274 |
ribosomal small subunit biogenesis |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.