Search Results
Overview
| Uniprot ID | Q4KLL0 |
|---|---|
| Protein Name | Transcription elongation factor A protein 1 |
| Gene Name | Tcea1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 19 | MDKMVQKKNAAGALD |
| 242 | EMRKNLTKEAIREHQ |
| 252 | IREHQMAKTGGTQTD |
| 55 | MSVNAIRKQSTDEEV |
Function
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity)
Protein Sequence
10
MEDEVVRIAK
20
KMDKMVQKKN
30
AAGALDLLKE
40
LKNIPMTLEL
50
LQSTRIGMSV
60
NAIRKQSTDE
70
EVTSLAKSLI
80
KSWKKLLDGP
90
STDKDSEEKK
100
KEPAISSQNS
110
PEAREESSSS
120
SHVSSRKDET
130
NARDTYVSSF
140
PRAPSTSDSV
150
RLKCREMLAA
160
ALRTGDDYVA
170
IGADEEELGS
180
QIEEAIYQEI
190
RNTDMKYKNR
200
VRSRISNLKD
210
AKNPNLRKNV
220
LCGNIPPDLF
230
ARMTAEEMAS
240
DELKEMRKNL
250
TKEAIREHQM
260
AKTGGTQTDL
270
FTCGKCKKKN
280
CTYTQVQTRS
290
ADEPMTTFVV
300
CNECGNRWKF
C
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005669 | transcription factor TFIID complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003711 | transcription elongation factor activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0030218 | erythrocyte differentiation |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0061014 | positive regulation of mRNA catabolic process |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006368 | transcription elongation by RNA polymerase II |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.