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Overview

Uniprot ID	Q4KMP7
Protein Name	TBC1 domain family member 10B
Gene Name	TBC1D10B
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
784	RKLSLRRKADGPPGP

Function

Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A

Protein Sequence

10 METGTAPLVA 20 PPRRHGAPAA 30 PSPPPRGSRA 40 GPVVVVAPGP 50 PVTTATSAPV 60 TLVAPGEARP 70 AWVPGSAETS 80 APAPAPAPAP 90 APAVTGSTVV 100 VLTLEASPEA 110 PKPQLPSGPE 120 SPEPAAVAGV 130 ETSRALAAGA 140 DSPKTEEARP 150 SPAPGPGTPT 160 GTPTRTPSRT 170 APGALTAKPP 180 LAPKPGTTVA 190 SGVTARSASG 200 QVTGGHGAAA 210 ATSASAGQAP 220 EDPSGPGTGP 230 SGTCEAPVAV 240 VTVTPAPEPA 250 ENSQDLGSTS 260 SLGPGISGPR 270 GQAPDTLSYL 280 DSVSLMSGTL 290 ESLADDVSSM 300 GSDSEINGLA 310 LRKTDKYGFL 320 GGSQYSGSLE 330 SSIPVDVARQ 340 RELKWLDMFS 350 NWDKWLSRRF 360 QKVKLRCRKG 370 IPSSLRAKAW 380 QYLSNSKELL 390 EQNPGKFEEL 400 ERAPGDPKWL 410 DVIEKDLHRQ 420 FPFHEMFAAR 430 GGHGQQDLYR 440 ILKAYTIYRP 450 DEGYCQAQAP 460 VAAVLLMHMP 470 AEQAFWCLVQ 480 ICDKYLPGYY 490 SAGLEAIQLD 500 GEIFFALLRR 510 ASPLAHRHLR 520 RQRIDPVLYM 530 TEWFMCIFAR 540 TLPWASVLRV 550 WDMFFCEGVK 560 IIFRVALVLL 570 RHTLGSVEKL 580 RSCQGMYETM 590 EQLRNLPQQC 600 MQEDFLVHEV 610 TNLPVTEALI 620 ERENAAQLKK 630 WRETRGELQY 640 RPSRRLHGSR 650 AIHEERRRQQ 660 PPLGPSSSLL 670 SLPGLKSRGS 680 RAAGGAPSPP 690 PPVRRASAGP 700 APGPVVTAEG 710 LHPSLPSPTG 720 NSTPLGSSKE 730 TRKQEKERQK 740 QEKERQKQEK 750 EREKERQKQE 760 KEREKQEKER 770 EKQEKERQKQ 780 EKKAQGRKLS 790 LRRKADGPPG 800 PHDGGDRPSA EARQDAYF

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0043087	regulation of GTPase activity
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005096	GTPase activator activity
Biological Process	GO:0042147	retrograde transport, endosome to Golgi

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.