Search Results
Overview
| Uniprot ID | Q4KMQ2 |
|---|---|
| Protein Name | Anoctamin-6 |
| Gene Name | ANO6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 220 | YFILSRVKYQVINNV |
Function
Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts (PubMed:20056604, PubMed:21107324, PubMed:21908539, PubMed:22006324, PubMed:22946059). Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization (By similarity). Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes (By similarity)
Protein Sequence
10
MKKMSRNVLL
20
QMEEEEDDDD
30
GDIVLENLGQ
40
TIVPDLGSLE
50
SQHDFRTPEF
60
EEFNGKPDSL
70
FFNDGQRRID
80
FVLVYEDESR
90
KETNKKGTNE
100
KQRRKRQAYE
110
SNLICHGLQL
120
EATRSVLDDK
130
LVFVKVHAPW
140
EVLCTYAEIM
150
HIKLPLKPND
160
LKNRSSAFGT
170
LNWFTKVLSV
180
DESIIKPEQE
190
FFTAPFEKNR
200
MNDFYIVDRD
210
AFFNPATRSR
220
IVYFILSRVK
230
YQVINNVSKF
240
GINRLVNSGI
250
YKAAFPLHDC
260
KFRRQSEDPS
270
CPNERYLLYR
280
EWAHPRSIYK
290
KQPLDLIRKY
300
YGEKIGIYFA
310
WLGYYTQMLL
320
LAAVVGVACF
330
LYGYLNQDNC
340
TWSKEVCHPD
350
IGGKIIMCPQ
360
CDRLCPFWKL
370
NITCESSKKL
380
CIFDSFGTLV
390
FAVFMGVWVT
400
LFLEFWKRRQ
410
AELEYEWDTV
420
ELQQEEQARP
430
EYEARCTHVV
440
INEITQEEER
450
IPFTAWGKCI
460
RITLCASAVF
470
FWILLIIASV
480
IGIIVYRLSV
490
FIVFSAKLPK
500
NINGTDPIQK
510
YLTPQTATSI
520
TASIISFIII
530
MILNTIYEKV
540
AIMITNFELP
550
RTQTDYENSL
560
TMKMFLFQFV
570
NYYSSCFYIA
580
FFKGKFVGYP
590
GDPVYWLGKY
600
RNEECDPGGC
610
LLELTTQLTI
620
IMGGKAIWNN
630
IQEVLLPWIM
640
NLIGRFHRVS
650
GSEKITPRWE
660
QDYHLQPMGK
670
LGLFYEYLEM
680
IIQFGFVTLF
690
VASFPLAPLL
700
ALVNNILEIR
710
VDAWKLTTQF
720
RRLVPEKAQD
730
IGAWQPIMQG
740
IAILAVVTNA
750
MIIAFTSDMI
760
PRLVYYWSFS
770
VPPYGDHTSY
780
TMEGYINNTL
790
SIFKVADFKN
800
KSKGNPYSDL
810
GNHTTCRYRD
820
FRYPPGHPQE
830
YKHNIYYWHV
840
IAAKLAFIIV
850
MEHVIYSVKF
860
FISYAIPDVS
870
KRTKSKIQRE
880
KYLTQKLLHE
890
NHLKDMTKNM
900
GVIAERMIEA
910
VDNNLRPKSE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0034707 | chloride channel complex |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0035579 | specific granule membrane |
| Cellular Component | GO:0070821 | tertiary granule membrane |
| Molecular Function | GO:0005227 | calcium-activated cation channel activity |
| Molecular Function | GO:0005254 | chloride channel activity |
| Molecular Function | GO:0005229 | intracellularly calcium-gated chloride channel activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0017128 | phospholipid scramblase activity |
| Molecular Function | GO:0046983 | protein dimerization activity |
| Molecular Function | GO:0005247 | voltage-gated chloride channel activity |
| Molecular Function | GO:0005244 | voltage-gated monoatomic ion channel activity |
| Biological Process | GO:0002543 | activation of blood coagulation via clotting cascade |
| Biological Process | GO:0032060 | bleb assembly |
| Biological Process | GO:0007596 | blood coagulation |
| Biological Process | GO:0061590 | calcium activated phosphatidylcholine scrambling |
| Biological Process | GO:0061589 | calcium activated phosphatidylserine scrambling |
| Biological Process | GO:0070588 | calcium ion transmembrane transport |
| Biological Process | GO:1902476 | chloride transmembrane transport |
| Biological Process | GO:0034220 | monoatomic ion transmembrane transport |
| Biological Process | GO:0045794 | negative regulation of cell volume |
| Biological Process | GO:0097045 | phosphatidylserine exposure on blood platelet |
| Biological Process | GO:0017121 | plasma membrane phospholipid scrambling |
| Biological Process | GO:0046931 | pore complex assembly |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0030501 | positive regulation of bone mineralization |
| Biological Process | GO:0034767 | positive regulation of monoatomic ion transmembrane transport |
| Biological Process | GO:0090026 | positive regulation of monocyte chemotaxis |
| Biological Process | GO:0060100 | positive regulation of phagocytosis, engulfment |
| Biological Process | GO:1903766 | positive regulation of potassium ion export across plasma membrane |
| Biological Process | GO:0035590 | purinergic nucleotide receptor signaling pathway |
| Biological Process | GO:0035725 | sodium ion transmembrane transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.