Search Results

Overview

Uniprot IDQ4KWH8
Protein Name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
Gene NamePLCH1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
776 GLPVDCCKDQTRVVD

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes

Protein Sequence

10 MADLEVYKNL 20 SPEKVERCMS 30 VMQSGTQMIK 40 LKRGTKGLVR 50 LFYLDEHRTR 60 LRWRPSRKSE 70 KAKILIDSIY 80 KVTEGRQSEI 90 FHRQAEGNFD 100 PSCCFTIYHG 110 NHMESLDLIT 120 SNPEEARTWI 130 TGLKYLMAGI 140 SDEDSLAKRQ 150 RTHDQWVKQT 160 FEEADKNGDG 170 LLNIEEIHQL 180 MHKLNVNLPR 190 RKVRQMFQEA 200 DTDENQGTLT 210 FEEFCVFYKM 220 MSLRRDLYLL 230 LLSYSDKKDH 240 LTVEELAQFL 250 KVEQKMNNVT 260 TDYCLDIIKK 270 FEVSEENKVK 280 NVLGIEGFTN 290 FMRSPACDIF 300 NPLHHEVYQD 310 MDQPLCNYYI 320 ASSHNTYLTG 330 DQLLSQSKVD 340 MYARVLQEGC 350 RCVEVDCWDG 360 PDGEPVVHHG 370 YTLTSKILFR 380 DVVETINKHA 390 FVKNEFPVIL 400 SIENHCSIQQ 410 QRKIAQYLKG 420 IFGDKLDLSS 430 VDTGECKQLP 440 SPQSLKGKIL 450 VKGKKLPYHL 460 GDDAEEGEVS 470 DEDSADEIED 480 ECKFKLHYSN 490 GTTEHQVESF 500 IRKKLESLLK 510 ESQIRDKEDP 520 DSFTVRALLK 530 ATHEGLNAHL 540 KQSPDVKESG 550 KKSHGRSLMT 560 NFGKHKKTTK 570 SRSKSYSTDD 580 EEDTQQSTGK 590 EGGQLYRLGR 600 RRKTMKLCRE 610 LSDLVVYTNS 620 VAAQDIVDDG 630 TTGNVLSFSE 640 TRAHQVVQQK 650 SEQFMIYNQK 660 QLTRIYPSAY 670 RIDSSNFNPL 680 PYWNAGCQLV 690 ALNYQSEGRM 700 MQLNRAKFKA 710 NGNCGYVLKP 720 QQMCKGTFNP 730 FSGDPLPANP 740 KKQLILKVIS 750 GQQLPKPPDS 760 MFGDRGEIID 770 PFVEVEIIGL 780 PVDCCKDQTR 790 VVDDNGFNPV 800 WEETLTFTVH 810 MPEIALVRFL 820 VWDHDPIGRD 830 FVGQRTVTFS 840 SLVPGYRHVY 850 LEGLTEASIF 860 VHITINEIYG 870 KWSPLILNPS 880 YTILHFLGAT 890 KNRQLQGLKG 900 LFNKNPRHSS 910 SENNSHYVRK 920 RSIGDRILRR 930 TASAPAKGRK 940 KSKMGFQEMV 950 EIKDSVSEAT 960 RDQDGVLRRT 970 TRSLQARPVS 980 MPVDRNLLGA 990 LSLPVSETAK 1000 DIEGKENSLA 1010 EDKDGRRKGK 1020 ASIKDPHFLN 1030 FNKKLSSSSS 1040 ALLHKDTSQG 1050 DTIVSTAHMS 1060 VTGEQLGMSS 1070 PRGGRTTSNA 1080 TSNCQENPCP 1090 SKSLSPKQHL 1100 APDPVVNPTQ 1110 DLHGVKIKEK 1120 GNPEDFVEGK 1130 SILSGSVLSH 1140 SNLEIKNLEG 1150 NRGKGRAATS 1160 FSLSDVSMLC 1170 SDIPDLHSTA 1180 ILQESVISHL 1190 IDNVTLTNEN 1200 EPGSSISALI 1210 GQFDETNNQA 1220 LTVVSHLHNT 1230 SVMSGHCPLP 1240 SLGLKMPIKH 1250 GFCKGKSKSS 1260 FLCSSPELIA 1270 LSSSETTKHA 1280 TNTVYETTCT 1290 PISKTKPDDD 1300 LSSKAKTAAL 1310 ESNLPGSPNT 1320 SRGWLPKSPT 1330 KGEDWETLKS 1340 CSPASSPDLT 1350 LEDVIADPTL 1360 CFNSGESSLV 1370 EIDGESENLS 1380 LTTCEYRREG 1390 TSQLASPLKL 1400 KYNQGVVEHF 1410 QRGLRNGYCK 1420 ETLRPSVPEI 1430 FNNIQDVKTQ 1440 SISYLAYQGA 1450 GFVHNHFSDS 1460 DAKMFQTCVP 1470 QQSSAQDMHV 1480 PVPKQLAHLP 1490 LPALKLPSPC 1500 KSKSLGDLTS 1510 EDIACNFESK 1520 YQCISKSFVT 1530 TGIRDKKGVT 1540 VKTKSLEPID 1550 ALTEQLRKLV 1560 SFDQEDNCQV 1570 LYSKQDANQL 1580 PRALVRKLSS 1590 RSQSRVRNIA 1600 SRAKEKQEAN 1610 KQKVPNPSNG 1620 AGVVLRNKPS 1630 APTPAVNRHS 1640 TGSYIAGYLK 1650 NTKGGGLEGR 1660 GIPEGACTAL 1670 HYGHVDQFCS 1680 DNSVLQTEPS 1690 SDDKPEIYFL LRL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0140324 lysophospholipase C activity
Molecular Function GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity
Biological Process GO:0016042 lipid catabolic process
Biological Process GO:0046488 phosphatidylinositol metabolic process
Biological Process GO:0048015 phosphatidylinositol-mediated signaling
Biological Process GO:0051209 release of sequestered calcium ion into cytosol

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.