Search Results

Overview

Uniprot IDQ4LE39
Protein NameAT-rich interactive domain-containing protein 4B
Gene NameARID4B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1137 KKQKRSHKATVVNNK
1178 KSVSTGMKSHSTKSP
186 VDYISLDKKKALWFP
188 YISLDKKKALWFPAL
473 KPSLGSKKNLLESIP
904 GFSEVAEKRIKLLNN

Function

Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity)

Protein Sequence

10 MKALDEPPYL 20 TVGTDVSAKY 30 RGAFCEAKIK 40 TAKRLVKVKV 50 TFRHDSSTVE 60 VQDDHIKGPL 70 KVGAIVEVKN 80 LDGAYQEAVI 90 NKLTDASWYT 100 VVFDDGDEKT 110 LRRSSLCLKG 120 ERHFAESETL 130 DQLPLTNPEH 140 FGTPVIGKKT 150 NRGRRSNHIP 160 EEESSSSSSD 170 EDEDDRKQID 180 ELLGKVVCVD 190 YISLDKKKAL 200 WFPALVVCPD 210 CSDEIAVKKD 220 NILVRSFKDG 230 KFTSVPRKDV 240 HEITSDTAPK 250 PDAVLKQAFE 260 QALEFHKSRT 270 IPANWKTELK 280 EDSSSSEAEE 290 EEEEEDDEKE 300 KEDNSSEEEE 310 EIEPFPEERE 320 NFLQQLYKFM 330 EDRGTPINKR 340 PVLGYRNLNL 350 FKLFRLVHKL 360 GGFDNIESGA 370 VWKQVYQDLG 380 IPVLNSAAGY 390 NVKCAYKKYL 400 YGFEEYCRSA 410 NIEFQMALPE 420 KVVNKQCKEC 430 ENVKEIKVKE 440 ENETEIKEIK 450 MEEERNIIPR 460 EEKPIEDEIE 470 RKENIKPSLG 480 SKKNLLESIP 490 THSDQEKEVN 500 IKKPEDNENL 510 DDKDDDTTRV 520 DESLNIKVEA 530 EEEKAKSGDE 540 TNKEEDEDDE 550 EAEEEEEEEE 560 EEEDEDDDDN 570 NEEEEFECYP 580 PGMKVQVRYG 590 RGKNQKMYEA 600 SIKDSDVEGG 610 EVLYLVHYCG 620 WNVRYDEWIK 630 ADKIVRPADK 640 NVPKIKHRKK 650 IKNKLDKEKD 660 KDEKYSPKNC 670 KLRRLSKPPF 680 QTNPSPEMVS 690 KLDLTDAKNS 700 DTAHIKSIEI 710 TSILNGLQAS 720 ESSAEDSEQE 730 DERGAQDMDN 740 NGKEESKIDH 750 LTNNRNDLIS 760 KEEQNSSSLL 770 EENKVHADLV 780 ISKPVSKSPE 790 RLRKDIEVLS 800 EDTDYEEDEV 810 TKKRKDVKKD 820 TTDKSSKPQI 830 KRGKRRYCNT 840 EECLKTGSPG 850 KKEEKAKNKE 860 SLCMENSSNS 870 SSDEDEEETK 880 AKMTPTKKYN 890 GLEEKRKSLR 900 TTGFYSGFSE 910 VAEKRIKLLN 920 NSDERLQNSR 930 AKDRKDVWSS 940 IQGQWPKKTL 950 KELFSDSDTE 960 AAASPPHPAP 970 EEGVAEESLQ 980 TVAEEESCSP 990 SVELEKPPPV 1000 NVDSKPIEEK 1010 TVEVNDRKAE 1020 FPSSGSNSVL 1030 NTPPTTPESP 1040 SSVTVTEGSR 1050 QQSSVTVSEP 1060 LAPNQEEVRS 1070 IKSETDSTIE 1080 VDSVAGELQD 1090 LQSEGNSSPA 1100 GFDASVSSSS 1110 SNQPEPEHPE 1120 KACTGQKRVK 1130 DAQGGGSSSK 1140 KQKRSHKATV 1150 VNNKKKGKGT 1160 NSSDSEELSA 1170 GESITKSQPV 1180 KSVSTGMKSH 1190 STKSPARTQS 1200 PGKCGKNGDK 1210 DPDLKEPSNR 1220 LPKVYKWSFQ 1230 MSDLENMTSA 1240 ERITILQEKL 1250 QEIRKHYLSL 1260 KSEVASIDRR 1270 RKRLKKKERE 1280 SAATSSSSSS 1290 PSSSSITAAV 1300 MLTLAEPSMS 1310 SASQNGMSVE CR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:1902455 negative regulation of stem cell population maintenance
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:1902459 positive regulation of stem cell population maintenance
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.