Search Results
Overview
| Uniprot ID | Q4QQT4 |
|---|---|
| Protein Name | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform |
| Gene Name | Ppp2r1b |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 200 | VRRAAASKLGEFAKV |
| 267 | LRQAAEDKSWRVRYM |
| 278 | VRYMVADKFSELQKA |
| 554 | NVRFNVAKSLQKIGP |
Function
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit
Protein Sequence
10
MAGAAGPGTV
20
PGAAGGDGDD
30
SLYPIAVLID
40
ELRNEDVQLR
50
LNSIKKLSTI
60
ALALGVERTR
70
TELLPFLTDT
80
IYDEDEVLLA
90
LAEQLGNFTG
100
LVGGPDFAHC
110
LLPPLESLAT
120
VEETVVRDKA
130
VESLRQISQE
140
HTPVALEAHF
150
VPLVKRLASG
160
DWFTSRTSAC
170
GLFSVCYPRA
180
SNAVKAEIRQ
190
HFRSLCSDDT
200
PMVRRAAASK
210
LGEFAKVLEL
220
DSVKTEIVPL
230
FTNLASDEQD
240
SVRLLAVEAC
250
VSIAQLLSQD
260
DLEALVMPTL
270
RQAAEDKSWR
280
VRYMVADKFS
290
ELQKAVGPKI
300
ALSDLIPAFQ
310
SLLRDCEAEV
320
RAAAAHKVRE
330
LCENLPTEGR
340
ETVIMNQILP
350
YIKELVSDTN
360
QHVKSALASV
370
IMGLSTVLGK
380
ENTIEHLLPL
390
FLAQLKDECP
400
EVRLNIISNL
410
DCVNEVIGIR
420
QLSQSLLPAI
430
VELAEDAKWR
440
VRLAIIEYMP
450
LLAGQLGVEF
460
FDEKLNSLCM
470
AWLVDHVYAI
480
REAATNNLMK
490
LVQKFGTEWA
500
QNTIVPKVLV
510
MANDPNYLHR
520
MTTLFCINAL
530
SEACGKEITT
540
KQMLPIVLKM
550
AGDQVANVRF
560
NVAKSLQKIG
570
PILDTNALQG
580
EVKPVLQKLG
590
QDEDMDVKYF
600
AQEAISVLAL
A
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000159 | protein phosphatase type 2A complex |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0019888 | protein phosphatase regulator activity |
| Biological Process | GO:0060561 | apoptotic process involved in morphogenesis |
| Biological Process | GO:0051754 | meiotic sister chromatid cohesion, centromeric |
| Biological Process | GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| Biological Process | GO:0051225 | spindle assembly |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.