Search Results
Overview
| Uniprot ID | Q4QQV3 |
|---|---|
| Protein Name | Protein FAM162A |
| Gene Name | Fam162a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 63 | RHRVPLHKPTDFEKK |
Function
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly
Protein Sequence
10
MWSLRGLRLA
20
AGHCFRLCER
30
NVSSPLRLTR
40
NTDLKRINGF
50
CTKPQESPKA
60
PTQSYRHRVP
70
LHKPTDFEKK
80
ILLWSGRFKK
90
EEEIPETISF
100
EMLDAAKNKI
110
RVKVSYLMIA
120
LTVAGCVYMV
130
IEGKKAAKRH
140
ESLTSLNLER
150
KARLREEAAM
KAKAD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Biological Process | GO:0071456 | cellular response to hypoxia |
| Biological Process | GO:0051402 | neuron apoptotic process |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.