Overview
| Uniprot ID | Q4QQV8 |
|---|
| Protein Name | Charged multivesicular body protein 5 |
|---|
| Gene Name | Chmp5 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 11 |
FFGKAKPKAPPPSLT |
| 110 |
KTTVDAMKLGVKEMK |
| 9 |
NRFFGKAKPKAPPPS |
Function
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity)
Protein Sequence
10
MNRFFGKAKP
20
KAPPPSLTDC
30
IGTVDSRAES
40
IDKKISRLDA
50
ELVKYKDQIK
60
KMREGPAKNM
70
VKQKALRVLK
80
QKRMYEQQRD
90
NLAQQSFNME
100
QANYTIQSLK
110
DTKTTVDAMK
120
LGVKEMKKAY
130
KEVKIDQIED
140
LQDQLEDMME
150
DANEIQEALG
160
RSYGTPELDE
170
DDLEAELDAL
180
GDELLADEDS
190
SYLDEAASAP
200
AIPEGVPTDT
210
KNKDGVLVDE
FGLPQIPAS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:1904930 |
amphisome membrane |
| Cellular Component |
GO:0000421 |
autophagosome membrane |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0000815 |
ESCRT III complex |
| Cellular Component |
GO:0000776 |
kinetochore |
| Cellular Component |
GO:0005828 |
kinetochore microtubule |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0015630 |
microtubule cytoskeleton |
| Cellular Component |
GO:0030496 |
midbody |
| Cellular Component |
GO:0005771 |
multivesicular body |
| Cellular Component |
GO:0032585 |
multivesicular body membrane |
| Cellular Component |
GO:0005635 |
nuclear envelope |
| Cellular Component |
GO:0005643 |
nuclear pore |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Biological Process |
GO:0097352 |
autophagosome maturation |
| Biological Process |
GO:0006914 |
autophagy |
| Biological Process |
GO:0071222 |
cellular response to lipopolysaccharide |
| Biological Process |
GO:0071225 |
cellular response to muramyl dipeptide |
| Biological Process |
GO:0008333 |
endosome to lysosome transport |
| Biological Process |
GO:0030218 |
erythrocyte differentiation |
| Biological Process |
GO:1902774 |
late endosome to lysosome transport |
| Biological Process |
GO:0032511 |
late endosome to vacuole transport via multivesicular body sorting pathway |
| Biological Process |
GO:0007040 |
lysosome organization |
| Biological Process |
GO:0061952 |
midbody abscission |
| Biological Process |
GO:0007080 |
mitotic metaphase chromosome alignment |
| Biological Process |
GO:0071985 |
multivesicular body sorting pathway |
| Biological Process |
GO:0031468 |
nuclear membrane reassembly |
| Biological Process |
GO:0006997 |
nucleus organization |
| Biological Process |
GO:0001778 |
plasma membrane repair |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0010824 |
regulation of centrosome duplication |
| Biological Process |
GO:1901673 |
regulation of mitotic spindle assembly |
| Biological Process |
GO:0001919 |
regulation of receptor recycling |
| Biological Process |
GO:0043162 |
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| Biological Process |
GO:0006900 |
vesicle budding from membrane |
| Biological Process |
GO:0046761 |
viral budding from plasma membrane |
| Biological Process |
GO:0039702 |
viral budding via host ESCRT complex |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.