Search Results

Overview

Uniprot IDQ4QQW4
Protein NameHistone deacetylase 1
Gene NameHdac1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
412 ISICSSDKRIACEEE
432 EEGEGGRKNSSNFKK
438 RKNSSNFKKAKRVKT
444 FKKAKRVKTEDEKEK
451 KTEDEKEKDPEEKKE
473 KEEKPEAKGVKEEVK

Function

Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). As part of the SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (By similarity). Also functions as a deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3, STAT3, ZNF76 and TSHZ3 (By similarity). Deacetylates SP proteins, SP1 and SP3, and regulates their function (By similarity). Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons (By similarity). Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation (By similarity). Deacetylates TSHZ3 and regulates its transcriptional repressor activity (By similarity). Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B (By similarity). Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (By similarity). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase and delactylase by mediating decrotonylation ((2E)-butenoyl) and delactylation (lactoyl) of histones, respectively (By similarity)

Protein Sequence

10 MAQTQGTKRK 20 VCYYYDGDVG 30 NYYYGQGHPM 40 KPHRIRMTHN 50 LLLNYGLYRK 60 MEIYRPHKAN 70 AEEMTKYHSD 80 DYIKFLRSIR 90 PDNMSEYSKQ 100 MQRFNVGEDC 110 PVFDGLFEFC 120 QLSTGGSVAS 130 AVKLNKQQTD 140 IAVNWAGGLH 150 HAKKSEASGF 160 CYVNDIVLAI 170 LELLKYHQRV 180 LYIDIDIHHG 190 DGVEEAFYTT 200 DRVMTVSFHK 210 YGEYFPGTGD 220 LRDIGAGKGK 230 YYAVNYPLRD 240 GIDDESYEAI 250 FKPVMSKVME 260 MFQPSAVVLQ 270 CGSDSLSGDR 280 LGCFNLTIKG 290 HAKCVEFVKS 300 FNLPMLMLGG 310 GGYTIRNVAR 320 CWTYETAVAL 330 DTEIPNELPY 340 NDYFEYFGPD 350 FKLHISPSNM 360 TNQNTNEYLE 370 KIKQRLFENL 380 RMLPHAPGVQ 390 MQAIPEDAIP 400 EESGDEDEED 410 PDKRISICSS 420 DKRIACEEEF 430 SDSDEEGEGG 440 RKNSSNFKKA 450 KRVKTEDEKE 460 KDPEEKKEVT 470 EEEKTKEEKP 480 EAKGVKEEVK MA

Gene Ontology

Classification GO ID Description
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0030182 neuron differentiation
Biological Process GO:0042475 odontogenesis of dentin-containing tooth
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0032732 positive regulation of interleukin-1 production
Biological Process GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
Biological Process GO:0048714 positive regulation of oligodendrocyte differentiation
Biological Process GO:0031401 positive regulation of protein modification process
Biological Process GO:0048661 positive regulation of smooth muscle cell proliferation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0032760 positive regulation of tumor necrosis factor production
Biological Process GO:2000676 positive regulation of type B pancreatic cell apoptotic process
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0001975 response to amphetamine
Biological Process GO:0031000 response to caffeine
Biological Process GO:0055093 response to hyperoxia
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0009410 response to xenobiotic stimulus
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000792 heterochromatin
Cellular Component GO:0000118 histone deacetylase complex
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016581 NuRD complex
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0070822 Sin3-type complex
Cellular Component GO:0005667 transcription regulator complex
Cellular Component GO:0017053 transcription repressor complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0001046 core promoter sequence-specific DNA binding
Molecular Function GO:0019213 deacetylase activity
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0070888 E-box binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0004407 histone deacetylase activity
Molecular Function GO:0141221 histone deacetylase activity, hydrolytic mechanism
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0160009 histone decrotonylase activity
Molecular Function GO:0035851 Krueppel-associated box domain binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0051059 NF-kappaB binding
Molecular Function GO:0002039 p53 binding
Molecular Function GO:1990841 promoter-specific chromatin binding
Molecular Function GO:0033558 protein lysine deacetylase activity
Molecular Function GO:0160216 protein lysine delactylase activity
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Molecular Function GO:0003714 transcription corepressor activity
Molecular Function GO:0001222 transcription corepressor binding
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0036120 cellular response to platelet-derived growth factor stimulus
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0007623 circadian rhythm
Biological Process GO:0006346 DNA methylation-dependent constitutive heterochromatin formation
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0042733 embryonic digit morphogenesis
Biological Process GO:0007492 endoderm development
Biological Process GO:0009913 epidermal cell differentiation
Biological Process GO:0061029 eyelid development in camera-type eye
Biological Process GO:0061198 fungiform papilla formation
Biological Process GO:0060789 hair follicle placode formation
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0021766 hippocampus development
Biological Process GO:0060766 negative regulation of androgen receptor signaling pathway
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0043124 negative regulation of canonical NF-kappaB signal transduction
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0045814 negative regulation of gene expression, epigenetic
Biological Process GO:0046676 negative regulation of insulin secretion
Biological Process GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:2000757 negative regulation of peptidyl-lysine acetylation

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.