Overview
| Uniprot ID | Q4QRB4 |
|---|
| Protein Name | Tubulin beta-3 chain |
|---|
| Gene Name | Tubb3 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 58 |
YNEASSHKYVPRAIL |
Function
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (By similarity). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (By similarity). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (By similarity). TUBB3 plays a critical role in proper axon guidance and maintenance (By similarity). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Plays a role in dorsal root ganglion axon projection towards the spinal cord (By similarity)
Protein Sequence
10
MREIVHIQAG
20
QCGNQIGAKF
30
WEVISDEHGI
40
DPSGNYVGDS
50
DLQLERISVY
60
YNEASSHKYV
70
PRAILVDLEP
80
GTMDSVRSGA
90
FGHLFRPDNF
100
IFGQSGAGNN
110
WAKGHYTEGA
120
ELVDSVLDVV
130
RKECENCDCL
140
QGFQLTHSLG
150
GGTGSGMGTL
160
LISKVREEYP
170
DRIMNTFSVV
180
PSPKVSDTVV
190
EPYNATLSIH
200
QLVENTDETY
210
CIDNEALYDI
220
CFRTLKLATP
230
TYGDLNHLVS
240
ATMSGVTTSL
250
RFPGQLNADL
260
RKLAVNMVPF
270
PRLHFFMPGF
280
APLTARGSQQ
290
YRALTVPELT
300
QQMFDAKNMM
310
AACDPRHGRY
320
LTVATVFRGR
330
MSMKEVDEQM
340
LAIQSKNSSY
350
FVEWIPNNVK
360
VAVCDIPPRG
370
LKMSSTFIGN
380
STAIQELFKR
390
ISEQFTAMFR
400
RKAFLHWYTG
410
EGMDEMEFTE
420
AESNMNDLVS
430
EYQQYQDATA
440
EEEGEMYEDD
450
DEESEAQGPK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030424 |
axon |
| Cellular Component |
GO:0071944 |
cell periphery |
| Cellular Component |
GO:0097542 |
ciliary tip |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0030175 |
filopodium |
| Cellular Component |
GO:0030426 |
growth cone |
| Cellular Component |
GO:0045171 |
intercellular bridge |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0005874 |
microtubule |
| Cellular Component |
GO:0015630 |
microtubule cytoskeleton |
| Cellular Component |
GO:0072686 |
mitotic spindle |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Cellular Component |
GO:0097229 |
sperm end piece |
| Cellular Component |
GO:0097228 |
sperm principal piece |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:1990890 |
netrin receptor binding |
| Molecular Function |
GO:0042277 |
peptide binding |
| Molecular Function |
GO:0005200 |
structural constituent of cytoskeleton |
| Biological Process |
GO:0007411 |
axon guidance |
| Biological Process |
GO:1990791 |
dorsal root ganglion development |
| Biological Process |
GO:0000226 |
microtubule cytoskeleton organization |
| Biological Process |
GO:0000278 |
mitotic cell cycle |
| Biological Process |
GO:0038007 |
netrin-activated signaling pathway |
| Biological Process |
GO:0030182 |
neuron differentiation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.