Search Results
Overview
| Uniprot ID | Q4V328 |
|---|---|
| Protein Name | GRIP1-associated protein 1 |
| Gene Name | GRIPAP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 230 | RLQEELAKLSEKLKK |
| 640 | QDILTNSKSRSGLEE |
Function
Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity)
Protein Sequence
10
MAQALSEEEF
20
QRMQAQLLEL
30
RTNNYQLSDE
40
LRKNGVELTS
50
LRQKVAYLDK
60
EFSKAQKALS
70
KSKKAQEVEV
80
LLSENEMLQA
90
KLHSQEEDFR
100
LQNSTLMAEF
110
SKLCSQMEQL
120
EQENQQLKEG
130
AAGAGVAQAG
140
PLVDGELLRL
150
QAENTALQKN
160
VAALQERYGK
170
EAGKFSAVSE
180
GQGDPPGGLA
190
PTVLAPMPLA
200
EVELKWEMEK
210
EEKRLLWEQL
220
QGLESSKQAE
230
TSRLQEELAK
240
LSEKLKKKQE
250
SFCRLQTEKE
260
TLFNDSRNKI
270
EELQQRKEAD
280
HKAQLARTQK
290
LQQELEAANQ
300
SLAELRDQRQ
310
GERLEHAAAL
320
RALQDQVSIQ
330
SADAQEQVEG
340
LLAENNALRT
350
SLAALEQIQT
360
AKTQELNMLR
370
EQTTGLAAEL
380
QQQQAEYEDL
390
MGQKDDLNSQ
400
LQESLRANSR
410
LLEQLQEIGQ
420
EKEQLTQELQ
430
EARKSAEKRK
440
AMLDELAMET
450
LQEKSQHKEE
460
LGAVRLRHEK
470
EVLGVRARYE
480
RELRELHEDK
490
KRQEEELRGQ
500
IREEKARTRE
510
LETLQQTVEE
520
LQAQVHSMDG
530
AKGWFERRLK
540
EAEESLQQQQ
550
QEQEEALKQC
560
REQHAAELKG
570
KEEELQDVRD
580
QLEQAQEERD
590
CHLKTISSLK
600
QEVKDTVDGQ
610
RILEKKGSAA
620
LKDLKRQLHL
630
ERKRADKLQE
640
RLQDILTNSK
650
SRSGLEELVL
660
SEMNSPSRTQ
670
TGDSSSISSF
680
SYREILREKE
690
SSAVPARSLS
700
SSPQAQPPRP
710
AELSDEEVAE
720
LFQRLAETQQ
730
EKWMLEEKVK
740
HLEVSSASMA
750
EDLCRKSAII
760
ETYVMDSRID
770
VSVAAGHTDR
780
SGLGSVLRDL
790
VKPGDENLRE
800
MNKKLQNMLE
810
EQLTKNMHLH
820
KDMEVLSQEI
830
VRLSKECVGP
840
PDPDLEPGET
S
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0098998 | extrinsic component of postsynaptic early endosome membrane |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0042734 | presynaptic membrane |
| Cellular Component | GO:0055038 | recycling endosome membrane |
| Molecular Function | GO:0005085 | guanyl-nucleotide exchange factor activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0035255 | ionotropic glutamate receptor binding |
| Biological Process | GO:1903910 | negative regulation of receptor clustering |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0099152 | regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane |
| Biological Process | GO:0099158 | regulation of recycling endosome localization within postsynapse |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.