Search Results
Overview
| Uniprot ID | Q4V7C1 |
|---|---|
| Protein Name | Centrosomal protein 43 |
| Gene Name | Cep43 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 275 | GWRSEPRKQVGGLAS |
Function
Required for anchoring microtubules to the centrosomes. Required for ciliation
Protein Sequence
10
MAATTAAVVA
20
EEDTELRDLL
30
VQTLENSGVL
40
NRIKAELRAA
50
VFLALEEQEK
60
VENKTPLVNE
70
SLKKFLNTKD
80
GRLVASLVAE
90
FLQFFNLDFT
100
LAVFHPETST
110
IQGLEGRENL
120
ARDLGIIEAE
130
GTVGGPLLLE
140
VIRRCQQKEK
150
GPTSVEGALD
160
LSDGHPPSKS
170
PEGKTSVNST
180
PSKIPRYKGQ
190
GKKKTSGQKS
200
GDKKTSSETS
210
QSEPSVSLSE
220
SKSKSSLHSL
230
VHETRIASFL
240
SNSTVDAKDK
250
SALCPDEDDV
260
EGDSFFDDPI
270
PKPEKTYGWR
280
SEPRKQVGGL
290
ASLSDKPHLR
300
SGLSSLAGAP
310
SLTDAESKRG
320
STVLKDLKLV
330
GEKIGSLGLG
340
SGEDEDYVDD
350
FNSASHRSEK
360
SELSIGEEIE
370
EDLSMGVEDV
380
NTSDKLDDLT
390
QDLTVSQLSD
VADYLEDVA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005814 | centriole |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0036064 | ciliary basal body |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0030292 | protein tyrosine kinase inhibitor activity |
| Biological Process | GO:0030030 | cell projection organization |
| Biological Process | GO:0034453 | microtubule anchoring |
| Biological Process | GO:0006469 | negative regulation of protein kinase activity |
| Biological Process | GO:0030307 | positive regulation of cell growth |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.