Search Results
Overview
| Uniprot ID | Q4V7C7 |
|---|---|
| Protein Name | Actin-related protein 3 |
| Gene Name | Actr3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 244 | DLVKEFNKYDTDGSK |
| 348 | RTVDARLKLSEELSG |
| 398 | YQVCHTKKDYEEIGP |
| 42 | IAIKESAKVGDQAQR |
Function
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis
Protein Sequence
10
MAGRLPACVV
20
DCGTGYTKLG
30
YAGNTEPQFI
40
IPSCIAIKES
50
AKVGDQAQRR
60
VMKGVDDLDF
70
FIGDEAIEKP
80
TYATKWPIRH
90
GIVEDWDLME
100
RFMEQVIFKY
110
LRAEPEDHYF
120
LLTEPPLNTP
130
ENREYTAEIM
140
FESFNVPGLY
150
IAVQAVLALA
160
ASWTSRQVGE
170
RTLTGTVIDS
180
GDGVTHVIPV
190
AEGYVIGSCI
200
KHIPIAGRDI
210
TYFIQQLLRD
220
REVGIPPEQS
230
LETAKAVKER
240
YSYVCPDLVK
250
EFNKYDTDGS
260
KWIKQYTGVN
270
AISKKEFSID
280
VGYERFLGPE
290
IFFHPEFANP
300
DFTQPISEVV
310
DEVIQNCPID
320
VRRPLYKNIV
330
LSGGSTMFRD
340
FGRRLQRDLK
350
RTVDARLKLS
360
EELSGGRLKP
370
KPIDVQVITH
380
HMQRYAVWFG
390
GSMLASTPEF
400
YQVCHTKKDY
410
EEIGPSICRH
NPVFGVMS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005884 | actin filament |
| Biological Process | GO:0030838 | positive regulation of actin filament polymerization |
| Biological Process | GO:0048711 | positive regulation of astrocyte differentiation |
| Biological Process | GO:0050775 | positive regulation of dendrite morphogenesis |
| Biological Process | GO:0061003 | positive regulation of dendritic spine morphogenesis |
| Biological Process | GO:0010763 | positive regulation of fibroblast migration |
| Biological Process | GO:0051491 | positive regulation of filopodium assembly |
| Biological Process | GO:0010592 | positive regulation of lamellipodium assembly |
| Biological Process | GO:0045666 | positive regulation of neuron differentiation |
| Biological Process | GO:1903078 | positive regulation of protein localization to plasma membrane |
| Biological Process | GO:0090314 | positive regulation of protein targeting to membrane |
| Biological Process | GO:0051965 | positive regulation of synapse assembly |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0099173 | postsynapse organization |
| Biological Process | GO:0098974 | postsynaptic actin cytoskeleton organization |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:0043519 | regulation of myosin II filament organization |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:0071503 | response to heparin |
| Biological Process | GO:0061843 | Sertoli cell barrier remodeling |
| Biological Process | GO:0007283 | spermatogenesis |
| Biological Process | GO:0051653 | spindle localization |
| Cellular Component | GO:0061831 | apical ectoplasmic specialization |
| Cellular Component | GO:0061828 | apical tubulobulbar complex |
| Cellular Component | GO:0005885 | Arp2/3 protein complex |
| Cellular Component | GO:0061832 | basal ectoplasmic specialization |
| Cellular Component | GO:0005903 | brush border |
| Cellular Component | GO:0031252 | cell leading edge |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0061830 | concave side of sperm head |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0060076 | excitatory synapse |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0030056 | hemidesmosome |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0061851 | leading edge of lamellipodium |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0002102 | podosome |
| Cellular Component | GO:0061825 | podosome core |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0035861 | site of double-strand break |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Biological Process | GO:0034314 | Arp2/3 complex-mediated actin nucleation |
| Biological Process | GO:0048708 | astrocyte differentiation |
| Biological Process | GO:0008356 | asymmetric cell division |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:0071347 | cellular response to interleukin-1 |
| Biological Process | GO:1905835 | cellular response to pyrimidine ribonucleotide |
| Biological Process | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| Biological Process | GO:0035984 | cellular response to trichostatin A |
| Biological Process | GO:1905837 | cellular response to triterpenoid |
| Biological Process | GO:0071356 | cellular response to tumor necrosis factor |
| Biological Process | GO:0071346 | cellular response to type II interferon |
| Biological Process | GO:0060271 | cilium assembly |
| Biological Process | GO:0007163 | establishment or maintenance of cell polarity |
| Biological Process | GO:0051321 | meiotic cell cycle |
| Biological Process | GO:0016344 | meiotic chromosome movement towards spindle pole |
| Biological Process | GO:0033206 | meiotic cytokinesis |
| Biological Process | GO:0030517 | negative regulation of axon extension |
| Biological Process | GO:1904171 | negative regulation of bleb assembly |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.