Search Results
Overview
| Uniprot ID | Q4V7D7 |
|---|---|
| Protein Name | Pre-mRNA-splicing factor RBM22 |
| Gene Name | Rbm22 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 139 | RPVGMLGKATSTSDM |
| 149 | STSDMLLKLARTTPY |
| 158 | ARTTPYYKRNRPHIC |
| 212 | INDPVADKLLKRAST |
Function
Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses
Protein Sequence
10
MATSLGSNTY
20
NRQNWEDADF
30
PILCQTCLGE
40
NPYIRMTKEK
50
YGKECKICAR
60
PFTVFRWCPG
70
VRMRFKKTEV
80
CQTCSKLKNV
90
CQTCLLDLEY
100
GLPIQVRDAG
110
LSFKDDMPKS
120
DVNKEYYTQN
130
MEREISNSDG
140
TRPVGMLGKA
150
TSTSDMLLKL
160
ARTTPYYKRN
170
RPHICSFWVK
180
GECKRGEECP
190
YRHEKPTDPD
200
DPLADQNIKD
210
RYYGINDPVA
220
DKLLKRASTM
230
PRLDPPEDKT
240
ITTLYVGGLG
250
DTITETDLRN
260
HFYQFGEIRT
270
VTVVQRQQCA
280
FIQFATRQAA
290
EVAAEKSFNK
300
LIVNGRRLNV
310
KWGRSQAARG
320
KEKEKDGTTD
330
SGIKLEPVPG
340
LPGALPPPPA
350
AEEEASANYF
360
NLPPSGPPAV
370
VNIALPPPPG
380
IAPPPPPGFG
390
PHLFHPMGPP
400
PPFMRAPGPI
410
HYPSQDPQRM
420
GAHAGKHSSP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0071014 | post-mRNA release spliceosomal complex |
| Cellular Component | GO:0071020 | post-spliceosomal complex |
| Cellular Component | GO:0000974 | Prp19 complex |
| Cellular Component | GO:0071006 | U2-type catalytic step 1 spliceosome |
| Cellular Component | GO:0071007 | U2-type catalytic step 2 spliceosome |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0036002 | pre-mRNA binding |
| Molecular Function | GO:0017070 | U6 snRNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0071466 | cellular response to xenobiotic stimulus |
| Biological Process | GO:0045292 | mRNA cis splicing, via spliceosome |
| Biological Process | GO:0046827 | positive regulation of protein export from nucleus |
| Biological Process | GO:0042307 | positive regulation of protein import into nucleus |
| Biological Process | GO:0033120 | positive regulation of RNA splicing |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.