Overview
| Uniprot ID | Q4V898 |
|---|
| Protein Name | RNA-binding motif protein, X chromosome |
|---|
| Gene Name | Rbmx |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 150 |
SRGPLPVKRGPPPRS |
| 217 |
RDDGYSTKDSYSSRD |
| 30 |
ALEAVFGKYGRIVEV |
Function
RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment
Protein Sequence
10
MVEADRPGKL
20
FIGGLNTETN
30
EKALEAVFGK
40
YGRIVEVLLM
50
KDRETNKSRG
60
FAFVTFESPA
70
DAKDAARDMN
80
GKSLDGKAIK
90
VEQATKPSFE
100
SGRRGLPPPP
110
RSRGPPRGLR
120
GGRGGSGGTR
130
GPPSRGGHMD
140
DGGYSMNFTL
150
SSSRGPLPVK
160
RGPPPRSGGP
170
PPKRSAPSGP
180
VRSSSGMGGR
190
APVSRGRDGY
200
GGPPRREPLP
210
SRRDVYLSPR
220
DDGYSTKDSY
230
SSRDYPSSRD
240
TRDYAPPPRD
250
YTYRDYGHSS
260
SRDDYPSRGY
270
SDRDGYGRER
280
DYSDHPSGGS
290
YRDSYESYGN
300
SRSAPPTRGP
310
PPSYGGSSRY
320
DDYSSSRDGY
330
GGSRDSYTSS
340
RSDLYSSGRD
350
RVGRQERGLP
360
PSMERGYPPP
370
RDSYSSSSRG
380
APRGGGRGGS
390
RSDRGGRSRY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0071013 |
catalytic step 2 spliceosome |
| Cellular Component |
GO:0000791 |
euchromatin |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0014069 |
postsynaptic density |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Cellular Component |
GO:0005681 |
spliceosomal complex |
| Cellular Component |
GO:0044530 |
supraspliceosomal complex |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0019904 |
protein domain specific binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:0003727 |
single-stranded RNA binding |
| Biological Process |
GO:0071347 |
cellular response to interleukin-1 |
| Biological Process |
GO:0006509 |
membrane protein ectodomain proteolysis |
| Biological Process |
GO:0006376 |
mRNA splice site recognition |
| Biological Process |
GO:0000398 |
mRNA splicing, via spliceosome |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0000381 |
regulation of alternative mRNA splicing, via spliceosome |
| Biological Process |
GO:0099175 |
regulation of postsynapse organization |
| Biological Process |
GO:0006366 |
transcription by RNA polymerase II |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.