Search Results
Overview
| Uniprot ID | Q4V8G6 |
|---|---|
| Protein Name | mRNA m(6)A methyltransferase |
| Gene Name | Mettl3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 27 | ERLQRRRKQDSGHLD |
Function
No function data available.
Protein Sequence
10
MSDTWSSIQA
20
HKKQLDSLRE
30
RLQRRRKQDS
40
GHLDLRNPEA
50
ALSPTFRSDS
60
PVPTAPTSSG
70
PKPSTTSIVP
80
ELATDPELEK
90
KLLHHLSDLA
100
LTLPTDAVSI
110
RLAISTPDAP
120
ATQDGVESLL
130
QKFAAQELIE
140
VKRGLLQDDA
150
HPTLVTYADH
160
SKLSAMMGAV
170
AEKKGLGEAA
180
GTITGQKRRA
190
EQDLTTVATF
200
TSSLASGLGS
210
STSEPAKEPA
220
KKSRKHAASD
230
VDLEIESLLN
240
QQSTKEQQSK
250
KVSQEILELL
260
NTTTAKEQSI
270
VEKFRSRGRA
280
QVQEFCDYGT
290
KEECMKASDA
300
DRPCRKLHFR
310
RIINKHTDES
320
LGDCSFLNTC
330
FHMDTCKYVH
340
YEIDACVDSE
350
SPGSKEHMPS
360
QELALTQSVG
370
GDSSADRLFP
380
PQWICCDIRY
390
LDVSILGKFA
400
VVMADPPWDI
410
HMELPYGTLT
420
DDEMRRLNIP
430
VLQDDGFLFL
440
WVTGRAMELG
450
RECLNLWGYE
460
RVDEIIWVKT
470
NQLQRIIRTG
480
RTGHWLNHGK
490
EHCLVGVKGN
500
PQGFNQGLDC
510
DVIVAEVRST
520
SHKPDEIYGM
530
IERLSPGTRK
540
IELFGRPHNV
550
QPNWITLGNQ
560
LDGIHLLDPD
570
VVARFKHRYP
580
DGVISKPKNL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Biological Process | GO:0031053 | primary miRNA processing |
| Biological Process | GO:0001510 | RNA methylation |
| Biological Process | GO:0043489 | RNA stabilization |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0036396 | RNA N6-methyladenosine methyltransferase complex |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0001734 | mRNA m(6)A methyltransferase activity |
| Molecular Function | GO:1990931 | mRNA N6-methyladenosine dioxygenase activity |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:1904047 | S-adenosyl-L-methionine binding |
| Biological Process | GO:0034644 | cellular response to UV |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0009048 | dosage compensation by inactivation of X chromosome |
| Biological Process | GO:0016556 | mRNA modification |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway |
| Biological Process | GO:1903679 | positive regulation of cap-independent translational initiation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.