Search Results
Overview
| Uniprot ID | Q4V8H8 |
|---|---|
| Protein Name | EH domain-containing protein 2 |
| Gene Name | Ehd2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 26 | RTVTSSLKELYRTKL |
| 32 | LKELYRTKLLPLEEH |
| 375 | FTKFHSLKPKLLEAL |
Function
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane
Protein Sequence
10
MFSWLKKGGA
20
RGQRSEAIRT
30
VTSSLKELYR
40
TKLLPLEEHY
50
RFGSFHSPAL
60
EDADFDGKPM
70
VLVAGQYSTG
80
KTSFIQYLLE
90
QEVPGSRVGP
100
EPTTDCFVAV
110
MHGETEGTVP
120
GNALVVDPEK
130
PFRKLNPFGN
140
TFLNRFMCAQ
150
LPNQVLESIS
160
IIDTPGILSG
170
AKQRVSRGYD
180
FPAVLRWFAE
190
RVDLIILLFD
200
AHKLEISDEF
210
SEAIGALRGH
220
EDKIRVVLNK
230
ADMVETQQLM
240
RVYGALMWAL
250
GKVVGTPEVL
260
RVYIGSFWSQ
270
PLLVPDNRRL
280
FELEEQDLFR
290
DIQGLPRHAA
300
LRKLNDLVKR
310
ARLVRVHAYI
320
ISYLKKEMPS
330
VFGKENKKKQ
340
LIFKLPVIFA
350
KIQLEHHISP
360
GDFPDCQKMQ
370
ELLMAHDFTK
380
FHSLKPKLLE
390
ALDEMLTHDI
400
AKLMPLLRQE
410
ELESVEAGVQ
420
GGAFEGTRMG
430
PFVERGPDEA
440
IEDGEEGSED
450
DAEWVVTKDK
460
SKYDEIFYNL
470
APADGKLSGS
480
KAKTWMVGTK
490
LPNSVLGRIW
500
KLSDVDRDGM
510
LDDEEFALAS
520
HLIEAKLEGH
530
GLPTNLPRRL
540
VPPSKRRQKG
SAE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0030139 | endocytic vesicle |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0055038 | recycling endosome membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Biological Process | GO:0060271 | cilium assembly |
| Biological Process | GO:0030866 | cortical actin cytoskeleton organization |
| Biological Process | GO:0032456 | endocytic recycling |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0097320 | plasma membrane tubulation |
| Biological Process | GO:2001137 | positive regulation of endocytic recycling |
| Biological Process | GO:1901741 | positive regulation of myoblast fusion |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.