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Overview

Uniprot ID	Q4V9H5
Protein Name	PHD finger protein 20-like protein 1
Gene Name	Phf20l1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
280	AKRARLNKITGLLAS

Function

Is a negative regulator of proteasomal degradation of a set of methylated proteins, including DNMT1 and SOX2 (By similarity). Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (By similarity)

Protein Sequence

10 MSKKPPNRPG 20 ITFEIGARLE 30 ALDYLQKWYP 40 SRIEKIDYEE 50 GKMLVHFERW 60 SHRYDEWIYW 70 DSNRLRPLER 80 PSLRKEGLKD 90 EEDLFDFKAG 100 EEVLARWTDC 110 RYYPAKIEAI 120 NKEGTFTVQF 130 YDGVIRCLKR 140 MHIKAMPEDA 150 KGQVKSQHPL 160 SWCCPIDPAG 170 SCNQSMGSED 180 WIALVKAAAA 190 AAAKNKTGSK 200 PRTSANSNKE 210 KERDGGKWFK 220 VPSKKAETST 230 CIVTAEIEKK 240 EELPTSSEPF 250 GLHIDSVPKI 260 VFPQPESTLT 270 NKRKNNQGNS 280 FQAKRARLNK 290 ITGLLASKAV 300 GVDGAEKKED 310 CSATAPVLEQ 320 AISPKPQSQK 330 KNEAVISSSA 340 NTQKPALLSS 350 TLSSGKARSK 360 KCKHESGESS 370 GCIKAPKSPL 380 APELIQAKDL 390 TLVSQLSSVI 400 NKTSSPQPVN 410 PPRPCKHSER 420 RRRSQRLATL 430 PMPDDSLEKL 440 SSSSSATDGK 450 VFSISSQNQQ 460 ESSVPEVPAI 470 AYVPLQKLGP 480 CLPLDLSCGS 490 EVTGSQAPDS 500 SYPGGECPRE 510 EKEETPLFAN 520 PTSKVVSDVK 530 GAAAATGILK 540 TEKKVKLEEK 550 TSTAFGKRKE 560 KDKERKEKRD 570 KDHYKPKQKK 580 KKKKKKKSKQ 590 HDYSDYEDSS 600 LDFLERCSSP 610 LTRSSGSSLA 620 PRSTFTEKTT 630 TYQYPRAILS 640 VDLSGENLSD 650 VEFLDDSSTE 660 SLLLSGDEYN 670 QDFDSTNFEE 680 SQDEDDALNE 690 IVRCICELDE 700 ENGFMIQCEE 710 CLCWQHSVCM 720 GLLEDSIPEQ 730 YICYICRDPP 740 GQRWNAKYRY 750 DKEWLNNGRM 760 YGLSFVKENY 770 SHLNAKKIVS 780 THHLLADVYG 790 ITEVLHGLQL 800 KIGILKNKHH 810 PDLRLWAYSG 820 KRKDQDQVVA 830 GAERKVILQD 840 TANSEGRKYV 850 QNHKEPPLKM 860 EETYITSEHS 870 YQKPQSFSQD 880 CHSLTDPGSS 890 DDDDVSSFEE 900 DGELHVADNS 910 HLLYSVKERG 920 VSEKNPASEN 930 KVFVYNDKKG 940 MEGPGDAHLQ 950 WQLNLLTHIE 960 NVQNEVTSRM 970 DLIEKEVDVL 980 ESWLDFTGEL 990 EPPDPLARLP 1000 QLKRHIKQLL 1010 LDMGKVQQIA TLCSV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0044545	NSL complex
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0140034	methylation-dependent protein binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006325	chromatin organization
Biological Process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process	GO:0042177	negative regulation of protein catabolic process
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.