Search Results
Overview
| Uniprot ID | Q4VCS5 |
|---|---|
| Protein Name | Angiomotin |
| Gene Name | AMOT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 156 | VQRLNPGKMHQDEGL |
Function
Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866)
Protein Sequence
10
MRNSEEQPSG
20
GTTVLQRLLQ
30
EQLRYGNPSE
40
NRSLLAIHQQ
50
ATGNGPPFPS
60
GSGNPGPQSD
70
VLSPQDHHQQ
80
LVAHAARQEP
90
QGQEIQSENL
100
IMEKQLSPRM
110
QNNEELPTYE
120
EAKVQSQYFR
130
GQQHASVGAA
140
FYVTGVTNQK
150
MRTEGRPSVQ
160
RLNPGKMHQD
170
EGLRDLKQGH
180
VRSLSERLMQ
190
MSLATSGVKA
200
HPPVTSAPLS
210
PPQPNDLYKN
220
PTSSSEFYKA
230
QGPLPNQHSL
240
KGMEHRGPPP
250
EYPFKGMPPQ
260
SVVCKPQEPG
270
HFYSEHRLNQ
280
PGRTEGQLMR
290
YQHPPEYGAA
300
RPAQDISLPL
310
SARNSQPHSP
320
TSSLTSGGSL
330
PLLQSPPSTR
340
LSPARHPLVP
350
NQGDHSAHLP
360
RPQQHFLPNQ
370
AHQGDHYRLS
380
QPGLSQQQQQ
390
QQQQHHHHHH
400
HQQQQQQQPQ
410
QQPGEAYSAM
420
PRAQPSSASY
430
QPVPADPFAI
440
VSRAQQMVEI
450
LSDENRNLRQ
460
ELEGCYEKVA
470
RLQKVETEIQ
480
RVSEAYENLV
490
KSSSKREALE
500
KAMRNKLEGE
510
IRRMHDFNRD
520
LRERLETANK
530
QLAEKEYEGS
540
EDTRKTISQL
550
FAKNKESQRE
560
KEKLEAELAT
570
ARSTNEDQRR
580
HIEIRDQALS
590
NAQAKVVKLE
600
EELKKKQVYV
610
DKVEKMQQAL
620
VQLQAACEKR
630
EQLEHRLRTR
640
LERELESLRI
650
QQRQGNCQPT
660
NVSEYNAAAL
670
MELLREKEER
680
ILALEADMTK
690
WEQKYLEENV
700
MRHFALDAAA
710
TVAAQRDTTV
720
ISHSPNTSYD
730
TALEARIQKE
740
EEEILMANKR
750
CLDMEGRIKT
760
LHAQIIEKDA
770
MIKVLQQRSR
780
KEPSKTEQLS
790
CMRPAKSLMS
800
ISNAGSGLLS
810
HSSTLTGSPI
820
MEEKRDDKSW
830
KGSLGILLGG
840
DYRAEYVPST
850
PSPVPPSTPL
860
LSAHSKTGSR
870
DCSTQTERGT
880
ESNKTAAVAP
890
ISVPAPVAAA
900
ATAAAITATA
910
ATITTTMVAA
920
APVAVAAAAA
930
PAAAAAPSPA
940
TAAATAAAVS
950
PAAAGQIPAA
960
ASVASAAAVA
970
PSAAAAAAVQ
980
VAPAAPAPVP
990
APALVPVPAP
1000
AAAQASAPAQ
1010
TQAPTSAPAV
1020
APTPAPTPTP
1030
AVAQAEVPAS
1040
PATGPGPHRL
1050
SIPSLTCNPD
1060
KTDGPVFHSN
1070
TLERKTPIQI
1080
LGQEPDAEMV
EYLI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0005923 | bicellular tight junction |
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030139 | endocytic vesicle |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0001725 | stress fiber |
| Molecular Function | GO:0043532 | angiostatin binding |
| Molecular Function | GO:0038023 | signaling receptor activity |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0007043 | cell-cell junction assembly |
| Biological Process | GO:0003365 | establishment of cell polarity involved in ameboidal cell migration |
| Biological Process | GO:0035329 | hippo signaling |
| Biological Process | GO:0016525 | negative regulation of angiogenesis |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0043116 | negative regulation of vascular permeability |
| Biological Process | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| Biological Process | GO:0045793 | positive regulation of cell size |
| Biological Process | GO:0051496 | positive regulation of stress fiber assembly |
| Biological Process | GO:0030334 | regulation of cell migration |
| Biological Process | GO:1905274 | regulation of modification of postsynaptic actin cytoskeleton |
Reference
PMID: N/A