Search Results

Overview

Uniprot IDQ52I78
Protein NameNicotinamide phosphoribosyltransferase
Gene NameNAMPT
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
330 KVLDILGKKFPVTEN
48 EKKTENSKIRKVKYE
88 QEAKEVYKEHFQDDV

Function

Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression

Protein Sequence

10 MNAAAEAEFN 20 ILLATDSYKV 30 THYKQYPPNT 40 SKVYSYFECR 50 EKKTENSKIR 60 KVKYEETVFY 70 GLQYILNKYL 80 KGKVVTKEKI 90 QEAKEVYKEH 100 FQDDVFNEKG 110 WNYILEKYDG 120 HLPIEVKAVP 130 EGSVIPRGNV 140 LFTVENTDPE 150 CYWLTNWIET 160 ILVQSWYPIT 170 VATNSREQKK 180 ILAKYLLETS 190 GNLDGLEYKL 200 HDFGYRGVSS 210 QETAGIGASA 220 HLVNFKGTDT 230 VAGIALIKKY 240 YGTKDPVPGY 250 SVPAAEHSTI 260 TAWGKDHEKD 270 AFEHIVTQFS 280 SVPVSVVSDS 290 YDIYNACEKI 300 WGEDLRHLIV 310 SRSTEAPLII 320 RPDSGNPLDT 330 VLKVLDILGK 340 KFPVTENSKG 350 YKLLPPYLRV 360 IQGDGVDINT 370 LQEIVEGMKQ 380 KKWSIENIAF 390 GSGGALLQKL 400 TRDLLNCSFK 410 CSYVVTNGLG 420 INVFKDPVAD 430 PNKRSKKGRL 440 SLHRTPGGNF 450 VTLEEGKGDL 460 EEYGHDLLHT 470 VFKNGKVTKS 480 YSFDEVRKNA 490 QLNIELEAAP H

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0047280 nicotinamide phosphoribosyltransferase activity
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0009435 NAD+ biosynthetic process
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005125 cytokine activity
Molecular Function GO:0042802 identical protein binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.