Search Results
Overview
| Uniprot ID | Q52KK3 |
|---|---|
| Protein Name | Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 |
| Gene Name | Slc25a51 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 154 | QDHKHHDKFTNTYQA |
Function
Mitochondrial membrane carrier protein that mediates the import of NAD(+) into mitochondria. Mitochondrial NAD(+) is required for glycolysis and mitochondrial respiration. Compared to SLC25A52, SLC25A51-mediated transport is essential for the import of NAD(+) in mitochondria. The transport mechanism, uniport or antiport, its electrogenicity and substrate selectivity, remain to be elucidated
Protein Sequence
10
MMGSEAHDKR
20
PPMLTSSNQD
30
LSPHLADVGQ
40
IKHYFCGCCA
50
AFNNVAITYP
60
VQKILFRQQL
70
YGIKTRDAIL
80
QLRKDGFRNL
90
YRGILPPLMQ
100
KTTTLALMFG
110
LYEDLSRLLR
120
KHVSNAPEFA
130
TRSVAALLAG
140
TTEAILTPLE
150
RVQTLLQDHK
160
HHDKFTNTYQ
170
AFRALRCHGV
180
AEYYRGLVPI
190
LFRNGFSNIL
200
FFGLRGPIKE
210
HLPTATTNSE
220
HLVNDFICGG
230
VLGAMLGFLS
240
FPVNVVKARI
250
QSQIGGPFQS
260
LPMVFKTIWI
270
ERDRKLINLF
280
RGAHLNYHRS
290
LISWGIINAT
YEFLLKIV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0051724 | NAD transmembrane transporter activity |
| Biological Process | GO:0019646 | aerobic electron transport chain |
| Biological Process | GO:1990549 | mitochondrial NAD transmembrane transport |
| Biological Process | GO:0034355 | NAD+ biosynthetic process via the salvage pathway |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.