Search Results

Overview

Uniprot IDQ52KS1
Protein NameATP-dependent 6-phosphofructokinase
Gene NamePfkm
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
107 RAAHNLVKRGITNLC
372 KRFDEAIKLRGRSFM
476 TKRTLPKKNLEQISA

Function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

Protein Sequence

10 MTHEEHHEAK 20 TLGIGKAIAV 30 LTSGGDAQGM 40 NAAVRAVVRV 50 GIFTGARVFF 60 VHEGYQGLVD 70 GGEHIREATW 80 ESVSMMLQLG 90 GTVIGSARCK 100 DFREREGRLR 110 AAHNLVKRGI 120 TNLCVIGGDG 130 SLTGADTFRS 140 EWSDLLNDLQ 150 KDGKITAEEA 160 TKSSYLNIVG 170 LVGSIDNDFC 180 GTDMTIGTDS 190 ALHRIVEIVD 200 AITTTAQSHQ 210 RTFVLEVMGR 220 HCGYLALVTS 230 LSCGADWVFI 240 PECPPDDDWE 250 EHLCRRLSET 260 RTRGSRLNII 270 IVAEGAIDKN 280 GKPITSEDIK 290 NLVVKRLGYD 300 TRVTVLGHVQ 310 RGGTPSAFDR 320 ILGSRMGVEA 330 VMALLEGTPD 340 TPACVVSLSG 350 NQAVRLPLME 360 CVQVTKDVTK 370 AMDEKRFDEA 380 IKLRGRSFMN 390 NWEVYKLLAH 400 VRPPVSKGGL 410 HTVAVMNVGA 420 PAAGMNAAVR 430 STVRIGLIQG 440 NRVLVVHDGF 450 EGLAKGQIEE 460 AGWSYVGGWT 470 GQGGSKLGTK 480 RTLPKKNLEQ 490 ISANITKYNI 500 QGLVIIGGFE 510 AYTGGLELME 520 GRKQFDELCI 530 PFVVIPATVS 540 NNVPGSDFSI 550 GADTALNTIC 560 TERSLQCSVA 570 SLNAGPYETC 580 DRIKQSAAGT 590 KRRVFIIETM 600 GGYCGYLATM 610 AGLAAGADAA 620 YIFEEPFTIR 630 DLQVNVEHLV 640 QKMKTTVKRG 650 LVLRNEKCNE 660 NYTTDFIFNL 670 YSEEGKGIFD 680 SRKNVLGHMQ 690 QGGSPTPFDR 700 NFATKMGAKA 710 MNWMSGKIKE 720 SYRNGRIFAN 730 TPDSGCVLGM 740 RKRALVFQPV 750 TELKDQTDFE 760 HRIPKEQWWL 770 KLRPILKILA 780 KYEIDLDTSD 790 HAHLEHISRK RSGEAAV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0003872 6-phosphofructokinase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0006002 fructose 6-phosphate metabolic process

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.