Search Results
Overview
| Uniprot ID | Q52LJ0 |
|---|---|
| Protein Name | tRNA-splicing ligase complex subunit FAM98B |
| Gene Name | FAM98B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 292 | SSGTSREKTACAINK |
| 299 | KTACAINKVLMGRVP |
| 327 | PEMPPWQKRQEGGGG |
Function
Accessory subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity and may function toward other RNAs (PubMed:21311021, PubMed:24870230). Could regulate the expression of PRMT1, a protein arginine N-methyltransferase (PubMed:28040436)
Protein Sequence
10
MRGPEPGPQP
20
TMEGDVLDTL
30
EALGYKGPLL
40
EEQALTKAAE
50
GGLSSPEFSE
60
LCIWLGSQIK
70
SLCNLEESIT
80
SAGRDDLESF
90
QLEISGFLKE
100
MACPYSVLIS
110
GDIKDRLKKK
120
EDCLKLLLFL
130
STELQASQIL
140
QNKKHKNSQL
150
DKNSEVYQEV
160
QAMFDTLGIP
170
KSTTSDIPHM
180
LNQVESKVKD
190
ILSKVQKNHV
200
GKPLLKMDLN
210
SEQAEQLERI
220
NDALSCEYEC
230
RRRMLMKRLD
240
VTVQSFGWSD
250
RAKVKTDDIA
260
RIYQPKRYAL
270
SPKTTITMAH
280
LLAAREDLSK
290
IIRTSSGTSR
300
EKTACAINKV
310
LMGRVPDRGG
320
RPNEIEPPPP
330
EMPPWQKRQE
340
GGGGRGGWGG
350
GGGGGGRGGG
360
GGGGGRGGWG
370
GGGGGWGGGG
380
GGGGGWGGGG
390
GGGRGGFQGR
400
GDYGGRGGYG
410
GRGGYGGRGY
420
GDPYGGGGGG
430
GGGGGGGGGY
RRY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0072669 | tRNA-splicing ligase complex |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008276 | protein methyltransferase activity |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0006479 | protein methylation |
| Biological Process | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.