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Overview

Uniprot IDQ52LW3
Protein NameRho GTPase-activating protein 29
Gene NameARHGAP29
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1014 ERHTPRTKIRPVSLP
1049 VNLDKFCKNPAFEGV
998 TPKPLSLKSDRSTNN

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis

Protein Sequence

10 MIAHKQKKTK 20 KKRAWASGQL 30 STDITTSEMG 40 LKSLSSNSIF 50 DPDYIKELVN 60 DIRKFSHMLL 70 YLKEAIFSDC 80 FKEVIHIRLE 90 ELLRVLKSIM 100 NKHQNLNSVD 110 LQNAAEMLTA 120 KVKAVNFTEV 130 NEENKNDLFQ 140 EVFSSIETLA 150 FTFGNILTNF 160 LMGDVGNDSL 170 LRLPVSRETK 180 SFENVSVESV 190 DSSSEKGNFS 200 PLELDNVLLK 210 NTDSIELALS 220 YAKTWSKYTK 230 NIVSWVEKKL 240 NLELESTRNM 250 VKLAEATRTN 260 IGIQEFMPLQ 270 SLFTNALLND 280 IESSHLLQQT 290 IAALQANKFV 300 QPLLGRKNEM 310 EKQRKEIKEL 320 WKQEQNKMLE 330 AENALKKAKL 340 LCMQRQDEYE 350 KAKSSMFRAE 360 EEHLSSSGGL 370 AKNLNKQLEK 380 KRRLEEEALQ 390 KVEEANELYK 400 VCVTNVEERR 410 NDLENTKREI 420 LAQLRTLVFQ 430 CDLTLKAVTV 440 NLFHMQHLQA 450 ASLADSLQSL 460 CDSAKLYDPG 470 QEYSEFVKAT 480 NSTEEEKVDG 490 NVNKHLNSSQ 500 PSGFGPANSL 510 EDVVRLPDSS 520 NKIEEDRCSN 530 SADITGPSFI 540 RSWTFGMFSD 550 SESTGGSSES 560 RSLDSESISP 570 GDFHRKLPRT 580 PSSGTMSSAD 590 DLDEREPPSP 600 SETGPNSLGT 610 FKKTLMSKAA 620 LTHKFRKLRS 630 PTKCRDCEGI 640 VVFQGVECEE 650 CLLVCHRKCL 660 ENLVIICGHQ 670 KLPGKIHLFG 680 AEFTQVAKKE 690 PDGIPFILKI 700 CASEIENRAL 710 CLQGIYRVCG 720 NKIKTEKLCQ 730 ALENGMHLVD 740 ISEFSSHDIC 750 DVLKLYLRQL 760 PEPFILFRLY 770 KEFIDLAKEI 780 QHVNEEQETK 790 KNSLEDKKWP 800 NMCIEINRIL 810 LKSKDLLRQL 820 PASNFNSLHF 830 LIVHLKRVVD 840 HAEENKMNSK 850 NLGVIFGPSL 860 IRPRPTTAPI 870 TISSLAEYSN 880 QARLVEFLIT 890 YSQKIFDGSL 900 QPQDVMCSIG 910 VVDQGCFPKP 920 LLSPEERDIE 930 RSMKSLFFSS 940 KEDIHTSESE 950 SKIFERATSF 960 EESERKQNAL 970 GKCDACLSDK 980 AQLLLDQEAE 990 SASQKIEDGK 1000 TPKPLSLKSD 1010 RSTNNVERHT 1020 PRTKIRPVSL 1030 PVDRLLLASP 1040 PNERNGRNMG 1050 NVNLDKFCKN 1060 PAFEGVNRKD 1070 AATTVCSKFN 1080 GFDQQTLQKI 1090 QDKQYEQNSL 1100 TAKTTMIMPS 1110 ALQEKGVTTS 1120 LQISGDHSIN 1130 ATQPSKPYAE 1140 PVRSVREASE 1150 RRSSDSYPLA 1160 PVRAPRTLQP 1170 QHWTTFYKPH 1180 APIISIRGNE 1190 EKPASPSAAV 1200 PPGTDHDPHG 1210 LVVKSMPDPD 1220 KASACPGQAT 1230 GQPKEDSEEL 1240 GLPDVNPMCQ 1250 RPRLKRMQQF 1260 EDLEGEIPQF V

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0030165 PDZ domain binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0051058 negative regulation of small GTPase mediated signal transduction
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Biological Process GO:0007266 Rho protein signal transduction

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.