Search Results
Overview
| Uniprot ID | Q52N47 |
|---|---|
| Protein Name | Integral membrane protein 2B |
| Gene Name | ITM2B |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 226 | IYRLCHDKETYKLQR |
Function
Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity)
Protein Sequence
10
MVKVTFNSAL
20
AQKEAKKXEP
30
KSGEEALIIP
40
PDTXAVDCKD
50
PDEVVPVGQR
60
RAWCWCMCFG
70
LAFMLAGVIL
80
GGAYLYKYFA
90
LQPDDVYYCG
100
IKYIKDDVIL
110
NEPPANAPAA
120
RYQTIEENIK
130
IFEEDGVEFI
140
SVPVPEFADS
150
DPANIVHDFN
160
KKLTAYLDLN
170
LDKCYVIPLN
180
TSIVMPPRNL
190
LELLINIKAG
200
TYLPQSYLIH
210
EHMVITDRIE
220
NIDHLGFYIY
230
RLCHDKETYK
240
LQRKETVKGI
250
QKREASNCAT
260
IRHFENKFAV
ETLICS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0030660 | Golgi-associated vesicle membrane |
| Cellular Component | GO:0031090 | organelle membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Biological Process | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.