Overview
| Uniprot ID | Q52NJ4 |
|---|
| Protein Name | ADP-ribosylation factor-like protein 3 |
|---|
| Gene Name | ARL3 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 11 |
LSILRKLKSAPDQEV |
Function
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity)
Protein Sequence
10
MGLLSILRKL
20
KSAPDQEVRI
30
LLLGLDNAGK
40
TTLLKQLASE
50
DISHITPTQG
60
FNIKSVQSQG
70
FKLNVWDIGG
80
QRKIRPYWRN
90
YFENTDILIY
100
VIDSADRKRF
110
EETGQELAEL
120
LEEEKLSCVP
130
VLIFANKQDL
140
LTAAPASEIA
150
EGLNLHTIRD
160
RVWQIQSCSA
170
LTGEGVQDGM
180
NWVCKNVNAK
KK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0005929 |
cilium |
| Cellular Component |
GO:0005881 |
cytoplasmic microtubule |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0030496 |
midbody |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0032391 |
photoreceptor connecting cilium |
| Cellular Component |
GO:0005876 |
spindle microtubule |
| Molecular Function |
GO:0019003 |
GDP binding |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0008017 |
microtubule binding |
| Biological Process |
GO:0060271 |
cilium assembly |
| Biological Process |
GO:0006893 |
Golgi to plasma membrane transport |
| Biological Process |
GO:0001822 |
kidney development |
| Biological Process |
GO:0000281 |
mitotic cytokinesis |
| Biological Process |
GO:0042461 |
photoreceptor cell development |
| Biological Process |
GO:1903441 |
protein localization to ciliary membrane |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0007264 |
small GTPase-mediated signal transduction |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.