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Overview

Uniprot IDQ52NJ5
Protein NameADP-ribosylation factor-like protein 1
Gene Name-
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
118 LEEEELRKAILVVFA
157 DRKWQIFKTSATKGT

Function

GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex. Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells

Protein Sequence

10 MGGFFSSIFS 20 SLFGTREMRI 30 LILGLDGAGK 40 TTILYRLQVG 50 EVVTTIPTIG 60 FNVETVTYKN 70 LKFQVWDLGG 80 QTSIRPYWRC 90 YYSNTDAVIY 100 VVDSCDRDRI 110 GISKSELVAM 120 LEEEELRKAI 130 LVVFANKQDM 140 EQAMTPSEMA 150 NSLGLPALKD 160 RKWQIFKTSA 170 TKGTGLDEAM 180 EWLVETLKSR Q

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005802 trans-Golgi network
Molecular Function GO:0008047 enzyme activator activity
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:1990583 phospholipase D activator activity
Biological Process GO:0007030 Golgi organization
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0034067 protein localization to Golgi apparatus
Biological Process GO:0042147 retrograde transport, endosome to Golgi
Biological Process GO:0009404 toxin metabolic process
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.