Overview
| Uniprot ID | Q53B90 |
|---|
| Protein Name | Ras-related protein Rab-43 |
|---|
| Gene Name | Rab43 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 63 |
KTLEIQGKRVKLQIW |
| 66 |
EIQGKRVKLQIWDTA |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Required for the structural integrity of the Golgi complex. Also controls the anterograde ER-to-Golgi transport of nascent G protein-coupled receptors (including ADRA2A, ADRA2B, ADRA2C, ADRA1B, ADRB2 and AGTR1) and regulates the ER sorting of GPCR members by virtue of its ability to interact directly. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis
Protein Sequence
10
MAGPGPGDQD
20
EHYDFLFKLV
30
LVGDASVGKT
40
CVVQRFKTGA
50
FSARQGSTIG
60
VDFTMKTLEI
70
QGKRVKLQIW
80
DTAGQERFRT
90
ITQSYYRSAN
100
GAILAYDISK
110
RSTFLSVPHW
120
IEDVRKYAGS
130
NIVQLLIGNK
140
SDLADLREVP
150
LAEAQSLAEH
160
YDILCAIETS
170
AKDSSNVEEA
180
FTRVATELIM
190
RHGGPMFSEK
200
NTDHIQLDSK
210
DIAESWGCGC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0033106 |
cis-Golgi network membrane |
| Cellular Component |
GO:0012505 |
endomembrane system |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0033116 |
endoplasmic reticulum-Golgi intermediate compartment membrane |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0045335 |
phagocytic vesicle |
| Cellular Component |
GO:0030670 |
phagocytic vesicle membrane |
| Cellular Component |
GO:0030672 |
synaptic vesicle membrane |
| Molecular Function |
GO:0003925 |
G protein activity |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0000045 |
autophagosome assembly |
| Biological Process |
GO:0071346 |
cellular response to type II interferon |
| Biological Process |
GO:0006888 |
endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process |
GO:0007030 |
Golgi organization |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0090382 |
phagosome maturation |
| Biological Process |
GO:1903358 |
regulation of Golgi organization |
| Biological Process |
GO:0035526 |
retrograde transport, plasma membrane to Golgi |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.