Search Results

Overview

Uniprot IDQ53EL6
Protein NameProgrammed cell death protein 4
Gene NamePDCD4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
108 DRRSRSGKGRGLPKK
115 KGRGLPKKGGAGGKG
306 TVLLSMSKGGKRKDS
311 MSKGGKRKDSVWGSG
96 LTVPTSPKGRLLDRR

Function

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity)

Protein Sequence

10 MDVENEQILN 20 VNPADPDNLS 30 DSLFSGDEEN 40 AGTEEIKNEI 50 NGNWISASSI 60 NEARINAKAK 70 RRLRKNSSRD 80 SGRGDSVSDS 90 GSDALRSGLT 100 VPTSPKGRLL 110 DRRSRSGKGR 120 GLPKKGGAGG 130 KGVWGTPGQV 140 YDVEEVDVKD 150 PNYDDDQENC 160 VYETVVLPLD 170 ERAFEKTLTP 180 IIQEYFEHGD 190 TNEVAEMLRD 200 LNLGEMKSGV 210 PVLAVSLALE 220 GKASHREMTS 230 KLLSDLCGTV 240 MSTTDVEKSF 250 DKLLKDLPEL 260 ALDTPRAPQL 270 VGQFIARAVG 280 DGILCNTYID 290 SYKGTVDCVQ 300 ARAALDKATV 310 LLSMSKGGKR 320 KDSVWGSGGG 330 QQSVNHLVKE 340 IDMLLKEYLL 350 SGDISEAEHC 360 LKELEVPHFH 370 HELVYEAIIM 380 VLESTGESTF 390 KMILDLLKSL 400 WKSSTITVDQ 410 MKRGYERIYN 420 EIPDINLDVP 430 HSYSVLERFV 440 EECFQAGIIS 450 KQLRDLCPSR 460 GRKRFVSEGD GGRLKPESY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006915 apoptotic process
Biological Process GO:0030509 BMP signaling pathway
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development
Biological Process GO:1900016 negative regulation of cytokine production involved in inflammatory response
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0043508 negative regulation of JUN kinase activity
Biological Process GO:1904761 negative regulation of myofibroblast differentiation
Biological Process GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation
Biological Process GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
Biological Process GO:2000353 positive regulation of endothelial cell apoptotic process
Biological Process GO:0050729 positive regulation of inflammatory response
Biological Process GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction
Biological Process GO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.