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Overview

Uniprot IDQ53ET0
Protein NameCREB-regulated transcription coactivator 2
Gene NameCRTC2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
25 NPRKFSEKIALQKQR
56 STRLQAQKLRLAYTR

Function

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR)

Protein Sequence

10 MATSGANGPG 20 SATASASNPR 30 KFSEKIALQK 40 QRQAEETAAF 50 EEVMMDIGST 60 RLQAQKLRLA 70 YTRSSHYGGS 80 LPNVNQIGSG 90 LAEFQSPLHS 100 PLDSSRSTRH 110 HGLVERVQRD 120 PRRMVSPLRR 130 YTRHIDSSPY 140 SPAYLSPPPE 150 SSWRRTMAWG 160 NFPAEKGQLF 170 RLPSALNRTS 180 SDSALHTSVM 190 NPSPQDTYPG 200 PTPPSILPSR 210 RGGILDGEMD 220 PKVPAIEENL 230 LDDKHLLKPW 240 DAKKLSSSSS 250 RPRSCEVPGI 260 NIFPSPDQPA 270 NVPVLPPAMN 280 TGGSLPDLTN 290 LHFPPPLPTP 300 LDPEETAYPS 310 LSGGNSTSNL 320 THTMTHLGIS 330 RGMGLGPGYD 340 APGLHSPLSH 350 PSLQSSLSNP 360 NLQASLSSPQ 370 PQLQGSHSHP 380 SLPASSLARH 390 VLPTTSLGHP 400 SLSAPALSSS 410 SSSSSTSSPV 420 LGAPSYPAST 430 PGASPHHRRV 440 PLSPLSLLAG 450 PADARRSQQQ 460 LPKQFSPTMS 470 PTLSSITQGV 480 PLDTSKLSTD 490 QRLPPYPYSS 500 PSLVLPTQPH 510 TPKSLQQPGL 520 PSQSCSVQSS 530 GGQPPGRQSH 540 YGTPYPPGPS 550 GHGQQSYHRP 560 MSDFNLGNLE 570 QFSMESPSAS 580 LVLDPPGFSE 590 GPGFLGGEGP 600 MGGPQDPHTF 610 NHQNLTHCSR 620 HGSGPNIILT 630 GDSSPGFSKE 640 IAAALAGVPG 650 FEVSAAGLEL 660 GLGLEDELRM 670 EPLGLEGLNM 680 LSDPCALLPD 690 PAVEESFRSD RLQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0008140 cAMP response element binding protein binding
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0051289 protein homotetramerization

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.