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Overview

Uniprot IDQ53EZ4
Protein NameCentrosomal protein of 55 kDa
Gene NameCEP55
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
13 TKDLIKSKWGSKPSN

Function

Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986)

Protein Sequence

10 MSSRSTKDLI 20 KSKWGSKPSN 30 SKSETTLEKL 40 KGEIAHLKTS 50 VDEITSGKGK 60 LTDKERHRLL 70 EKIRVLEAEK 80 EKNAYQLTEK 90 DKEIQRLRDQ 100 LKARYSTTTL 110 LEQLEETTRE 120 GERREQVLKA 130 LSEEKDVLKQ 140 QLSAATSRIA 150 ELESKTNTLR 160 LSQTVAPNCF 170 NSSINNIHEM 180 EIQLKDALEK 190 NQQWLVYDQQ 200 REVYVKGLLA 210 KIFELEKKTE 220 TAAHSLPQQT 230 KKPESEGYLQ 240 EEKQKCYNDL 250 LASAKKDLEV 260 ERQTITQLSF 270 ELSEFRRKYE 280 ETQKEVHNLN 290 QLLYSQRRAD 300 VQHLEDDRHK 310 TEKIQKLREE 320 NDIARGKLEE 330 EKKRSEELLS 340 QVQFLYTSLL 350 KQQEEQTRVA 360 LLEQQMQACT 370 LDFENEKLDR 380 QHVQHQLHVI 390 LKELRKARNQ 400 ITQLESLKQL 410 HEFAITEPLV 420 TFQGETENRE 430 KVAASPKSPT 440 AALNESLVEC 450 PKCNIQYPAT 460 EHRDLLVHVE YCSK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005814 centriole
Cellular Component GO:0016020 membrane
Cellular Component GO:0030496 midbody
Molecular Function GO:0042802 identical protein binding
Biological Process GO:1904888 cranial skeletal system development
Biological Process GO:0045184 establishment of protein localization
Biological Process GO:0061952 midbody abscission
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Cellular Component GO:0005813 centrosome
Cellular Component GO:0032154 cleavage furrow
Cellular Component GO:0005829 cytosol
Cellular Component GO:0090543 Flemming body
Cellular Component GO:0045171 intercellular bridge

Reference

PMID: N/A