Overview
| Uniprot ID | Q53F19 |
|---|
| Protein Name | Nuclear cap-binding protein subunit 3 |
|---|
| Gene Name | NCBP3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 282 |
RRSQYYMKYGNPNYG |
| 329 |
DVGLTSYKHRHSGLV |
| 487 |
RPPVSSTKSDIRQRL |
| 70 |
TSRRYENKAGSFITG |
Function
Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858)
Protein Sequence
10
MAAVRGLRVS
20
VKAEAPAGPA
30
LGLPSPEAES
40
GVDRGEPEPM
50
EVEEGELEIV
60
PVRRSLKELI
70
PDTSRRYENK
80
AGSFITGIDV
90
TSKEAIEKKE
100
QRAKRFHFRS
110
EVNLAQRNVA
120
LDRDMMKKAI
130
PKVRLETIYI
140
CGVDEMSTQD
150
VFSYFKEYPP
160
AHIEWLDDTS
170
CNVVWLDEMT
180
ATRALINMSS
190
LPAQDKIRSR
200
DASEDKSAEK
210
RKKDKQEDSS
220
DDDEAEEGEV
230
EDENSSDVEL
240
DTLSQVEEES
250
LLRNDLRPAN
260
KLAKGNRLFM
270
RFATKDDKKE
280
LGAARRSQYY
290
MKYGNPNYGG
300
MKGILSNSWK
310
RRYHSRRIQR
320
DVIKKRALIG
330
DDVGLTSYKH
340
RHSGLVNVPE
350
EPIEEEEEEE
360
EEEEEEEEED
370
QDMDADDRVV
380
VEYHEELPAL
390
KQPRERSASR
400
RSSASSSDSD
410
EMDYDLELKM
420
ISTPSPKKSM
430
KMTMYADEVE
440
SQLKNIRNSM
450
RADSVSSSNI
460
KNRIGNKLPP
470
EKFADVRHLL
480
DEKRQHSRPR
490
PPVSSTKSDI
500
RQRLGKRPHS
510
PEKAFSSNPV
520
VRREPSSDVH
530
SRLGVPRQDS
540
KGLYADTREK
550
KSGNLWTRLG
560
SAPKTKEKNT
570
KKVDHRAPGA
580
EEDDSELQRA
590
WGALIKEKEQ
600
SRQKKSRLDN
610
LPSLQIEVSR
620
ESSSGSEAES
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0034518 |
RNA cap binding complex |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0000340 |
RNA 7-methylguanosine cap binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0000339 |
RNA cap binding |
| Biological Process |
GO:0006370 |
7-methylguanosine mRNA capping |
| Biological Process |
GO:0051607 |
defense response to virus |
| Biological Process |
GO:0006406 |
mRNA export from nucleus |
| Biological Process |
GO:0042789 |
mRNA transcription by RNA polymerase II |
| Biological Process |
GO:0035194 |
regulatory ncRNA-mediated post-transcriptional gene silencing |
| Biological Process |
GO:0006408 |
snRNA export from nucleus |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.