Overview
| Uniprot ID | Q53FA7 |
|---|
| Protein Name | Quinone oxidoreductase PIG3 |
|---|
| Gene Name | TP53I3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 176 |
LVTAGSQKKLQMAEK |
| 194 |
AAGFNYKKEDFSEAT |
Function
NADPH:quinone reductase which expression is induced by p53/TP53 and is involved in both the DNA damage response through homologous recombination repair, and p53-mediated apoptosis (PubMed:19349281, PubMed:33782397). Catalyzes the NADPH-dependent reduction of quinones, exhibiting a low enzymatic activity with beta-naphthoquinones and a strong preference for the ortho-quinone isomer (1,2-beta-naphthoquinone) over the para isomer (1,4-beta-naphthoquinone). Also displays a low reductase activity for non-quinone compounds such as diamine and 2,6-dichloroindophenol (in vitro) (PubMed:19349281). The reduction of 1,2-naphthoquinone concurrently generates reactive oxygen species (ROS), which may trigger apoptosis downstream of p53/TP53 (PubMed:19349281)
Protein Sequence
10
MLAVHFDKPG
20
GPENLYVKEV
30
AKPSPGEGEV
40
LLKVAASALN
50
RADLMQRQGQ
60
YDPPPGASNI
70
LGLEASGHVA
80
ELGPGCQGHW
90
KIGDTAMALL
100
PGGGQAQYVT
110
VPEGLLMPIP
120
EGLTLTQAAA
130
IPEAWLTAFQ
140
LLHLVGNVQA
150
GDYVLIHAGL
160
SGVGTAAIQL
170
TRMAGAIPLV
180
TAGSQKKLQM
190
AEKLGAAAGF
200
NYKKEDFSEA
210
TLKFTKGAGV
220
NLILDCIGGS
230
YWEKNVNCLA
240
LDGRWVLYGL
250
MGGGDINGPL
260
FSKLLFKRGS
270
LITSLLRSRD
280
NKYKQMLVNA
290
FTEQILPHFS
300
TEGPQRLLPV
310
LDRIYPVTEI
320
QEAHKYMEAN
330
KNIGKIVLEL
PQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Molecular Function |
GO:0003960 |
quinone reductase (NADPH) activity |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:1903409 |
reactive oxygen species biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.