Overview
| Uniprot ID | Q53FP2 |
|---|
| Protein Name | Novel acetylcholine receptor chaperone |
|---|
| Gene Name | TMEM35A |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 87 |
TLVPGRPKDVANFFL |
Function
Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain (PubMed:26875622, PubMed:27789755, PubMed:28445721, PubMed:32204458, PubMed:32783947). Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors (PubMed:26875622, PubMed:27789755, PubMed:28445721, PubMed:32204458, PubMed:32783947). Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (By similarity). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly (PubMed:28445721). Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (PubMed:32676916)
Protein Sequence
10
MASPRTVTIV
20
ALSVALGLFF
30
VFMGTIKLTP
40
RLSKDAYSEM
50
KRAYKSYVRA
60
LPLLKKMGIN
70
SILLRKSIGA
80
LEVACGIVMT
90
LVPGRPKDVA
100
NFFLLLLVLA
110
VLFFHQLVGD
120
PLKRYAHALV
130
FGILLTCRLL
140
IARKPEDRSS
150
EKKPLPGNAE
160
EQPSLYEKAP
QGKVKVS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0005778 |
peroxisomal membrane |
| Molecular Function |
GO:0030548 |
acetylcholine receptor regulator activity |
| Biological Process |
GO:0051131 |
chaperone-mediated protein complex assembly |
| Biological Process |
GO:2000010 |
positive regulation of protein localization to cell surface |
Reference
PMID: N/A