Search Results
Overview
| Uniprot ID | Q53FZ2 |
|---|---|
| Protein Name | Acyl-coenzyme A synthetase ACSM3, mitochondrial |
| Gene Name | ACSM3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 572 | LPKTISGKTKRNELR |
Function
Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11772874). Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms (By similarity)
Protein Sequence
10
MLARVTRKML
20
RHAKCFQRLA
30
IFGSVRALHK
40
DNRTATPQNF
50
SNYESMKQDF
60
KLGIPEYFNF
70
AKDVLDQWTD
80
KEKAGKKPSN
90
PAFWWINRNG
100
EEMRWSFEEL
110
GSLSRKFANI
120
LSEACSLQRG
130
DRVILILPRV
140
PEWWLANVAC
150
LRTGTVLIPG
160
TTQLTQKDIL
170
YRLQSSKANC
180
IITNDVLAPA
190
VDAVASKCEN
200
LHSKLIVSEN
210
SREGWGNLKE
220
LMKHASDSHT
230
CVKTKHNEIM
240
AIFFTSGTSG
250
YPKMTAHTHS
260
SFGLGLSVNG
270
RFWLDLTPSD
280
VMWNTSDTGW
290
AKSAWSSVFS
300
PWIQGACVFT
310
HHLPRFEPTS
320
ILQTLSKYPI
330
TVFCSAPTVY
340
RMLVQNDITS
350
YKFKSLKHCV
360
SAGEPITPDV
370
TEKWRNKTGL
380
DIYEGYGQTE
390
TVLICGNFKG
400
MKIKPGSMGK
410
PSPAFDVKIV
420
DVNGNVLPPG
430
QEGDIGIQVL
440
PNRPFGLFTH
450
YVDNPSKTAS
460
TLRGNFYITG
470
DRGYMDKDGY
480
FWFVARADDV
490
ILSSGYRIGP
500
FEVENALNEH
510
PSVAESAVVS
520
SPDPIRGEVV
530
KAFVVLNPDY
540
KSHDQEQLIK
550
EIQEHVKKTT
560
APYKYPRKVE
570
FIQELPKTIS
580
GKTKRNELRK
KEWKTI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0043759 | 2-methylbutanoate-CoA ligase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0015645 | fatty acid ligase activity |
| Molecular Function | GO:0004321 | fatty-acyl-CoA synthase activity |
| Molecular Function | GO:0031956 | medium-chain fatty acid-CoA ligase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0018729 | propionate CoA-transferase activity |
| Molecular Function | GO:0050218 | propionate-CoA ligase activity |
| Biological Process | GO:0006637 | acyl-CoA metabolic process |
| Biological Process | GO:0042632 | cholesterol homeostasis |
| Biological Process | GO:0006633 | fatty acid biosynthetic process |
| Biological Process | GO:0008217 | regulation of blood pressure |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.