Search Results

Overview

Uniprot IDQ53GG5
Protein NamePDZ and LIM domain protein 3
Gene NamePDLIM3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
280 SVRAPVTKVHGGSGG
363 DTVTLYPKA******

Function

May play a role in the organization of actin filament arrays within muscle cells

Protein Sequence

10 MPQTVILPGP 20 APWGFRLSGG 30 IDFNQPLVIT 40 RITPGSKAAA 50 ANLCPGDVIL 60 AIDGFGTESM 70 THADAQDRIK 80 AAAHQLCLKI 90 DRGETHLWSP 100 QVSEDGKAHP 110 FKINLESEPQ 120 DGNYFEHKHN 130 IRPKPFVIPG 140 RSSGCSTPSG 150 IDCGSGRSTP 160 SSVSTVSTIC 170 PGDLKVAAKL 180 APNIPLEMEL 190 PGVKIVHAQF 200 NTPMQLYSDD 210 NIMETLQGQV 220 STALGETPLM 230 SEPTASVPPE 240 SDVYRMLHDN 250 RNEPTQPRQS 260 GSFRVLQGMV 270 DDGSDDRPAG 280 TRSVRAPVTK 290 VHGGSGGAQR 300 MPLCDKCGSG 310 IVGAVVKARD 320 KYRHPECFVC 330 ADCNLNLKQK 340 GYFFIEGELY 350 CETHARARTK 360 PPEGYDTVTL YPKA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031941 filamentous actin
Cellular Component GO:0001725 stress fiber
Cellular Component GO:0030018 Z disc
Molecular Function GO:0003779 actin binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0051371 muscle alpha-actinin binding
Molecular Function GO:0008307 structural constituent of muscle
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0007507 heart development
Biological Process GO:0061061 muscle structure development

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.