Overview
| Uniprot ID | Q53GQ0 |
|---|
| Protein Name | Very-long-chain 3-oxoacyl-CoA reductase |
|---|
| Gene Name | HSD17B12 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 244 |
TKLAKIRKPTLDKPS |
| 72 |
SYAEELAKHGMKVVL |
Function
Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation
Protein Sequence
10
MESALPAAGF
20
LYWVGAGTVA
30
YLALRISYSL
40
FTALRVWGVG
50
NEAGVGPGLG
60
EWAVVTGSTD
70
GIGKSYAEEL
80
AKHGMKVVLI
90
SRSKDKLDQV
100
SSEIKEKFKV
110
ETRTIAVDFA
120
SEDIYDKIKT
130
GLAGLEIGIL
140
VNNVGMSYEY
150
PEYFLDVPDL
160
DNVIKKMINI
170
NILSVCKMTQ
180
LVLPGMVERS
190
KGAILNISSG
200
SGMLPVPLLT
210
IYSATKTFVD
220
FFSQCLHEEY
230
RSKGVFVQSV
240
LPYFVATKLA
250
KIRKPTLDKP
260
SPETFVKSAI
270
KTVGLQSRTN
280
GYLIHALMGS
290
IISNLPSWIY
300
LKIVMNMNKS
310
TRAHYLKKTK
KN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0031012 |
extracellular matrix |
| Cellular Component |
GO:0009923 |
fatty acid elongase complex |
| Molecular Function |
GO:0005518 |
collagen binding |
| Molecular Function |
GO:0004303 |
estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
| Molecular Function |
GO:0001968 |
fibronectin binding |
| Molecular Function |
GO:0008201 |
heparin binding |
| Molecular Function |
GO:0016491 |
oxidoreductase activity |
| Molecular Function |
GO:0047045 |
testosterone dehydrogenase (NADP+) activity |
| Molecular Function |
GO:0141040 |
very-long-chain 3-oxoacyl-CoA reductase activity |
| Biological Process |
GO:0006702 |
androgen biosynthetic process |
| Biological Process |
GO:0006703 |
estrogen biosynthetic process |
| Biological Process |
GO:0019367 |
fatty acid elongation, saturated fatty acid |
| Biological Process |
GO:0035338 |
long-chain fatty-acyl-CoA biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.