Search Results
Overview
| Uniprot ID | Q53GS7 |
|---|---|
| Protein Name | mRNA export factor GLE1 |
| Gene Name | GLE1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 214 | AEHRHRAKILNLKLR |
Function
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC)
Protein Sequence
10
MPSEGRCWET
20
LKALRSSDKG
30
RLCYYRDWLL
40
RREDVLEECM
50
SLPKLSSYSG
60
WVVEHVLPHM
70
QENQPLSETS
80
PSSTSASALD
90
QPSFVPKSPD
100
ASSAFSPASP
110
ATPNGTKGKD
120
ESQHTESMVL
130
QSSRGIKVEG
140
CVRMYELVHR
150
MKGTEGLRLW
160
QEEQERKVQA
170
LSEMASEQLK
180
RFDEWKELKQ
190
HKEFQDLREV
200
MEKSSREALG
210
HQEKLKAEHR
220
HRAKILNLKL
230
REAEQQRVKQ
240
AEQERLRKEE
250
GQIRLRALYA
260
LQEEMLQLSQ
270
QLDASEQHKA
280
LLKVDLAAFQ
290
TRGNQLCSLI
300
SGIIRASSES
310
SYPTAESQAE
320
AERALREMRD
330
LLMNLGQEIT
340
RACEDKRRQD
350
EEEAQVKLQE
360
AQMQQGPEAH
370
KEPPAPSQGP
380
GGKQNEDLQV
390
KVQDITMQWY
400
QQLQDASMQC
410
VLTFEGLTNS
420
KDSQAKKIKM
430
DLQKAATIPV
440
SQISTIAGSK
450
LKEIFDKIHS
460
LLSGKPVQSG
470
GRSVSVTLNP
480
QGLDFVQYKL
490
AEKFVKQGEE
500
EVASHHEAAF
510
PIAVVASGIW
520
ELHPRVGDLI
530
LAHLHKKCPY
540
SVPFYPTFKE
550
GMALEDYQRM
560
LGYQVKDSKV
570
EQQDNFLKRM
580
SGMIRLYAAI
590
IQLRWPYGNR
600
QEIHPHGLNH
610
GWRWLAQILN
620
MEPLSDVTAT
630
LLFDFLEVCG
640
NALMKQYQVQ
650
FWKMLILIKE
660
DYFPRIEAIT
670
SSGQMGSFIR
680
LKQFLEKCLQ
690
HKDIPVPKGF
LTSSFWRS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005814 | centriole |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0036064 | ciliary basal body |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0005643 | nuclear pore |
| Cellular Component | GO:0044614 | nuclear pore cytoplasmic filaments |
| Cellular Component | GO:0005730 | nucleolus |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000822 | inositol hexakisphosphate binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0031369 | translation initiation factor binding |
| Biological Process | GO:0006406 | mRNA export from nucleus |
| Biological Process | GO:0006913 | nucleocytoplasmic transport |
| Biological Process | GO:0016973 | poly(A)+ mRNA export from nucleus |
| Biological Process | GO:0015031 | protein transport |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.