Search Results
Overview
| Uniprot ID | Q53H80 |
|---|---|
| Protein Name | Akirin-2 |
| Gene Name | AKIRIN2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 23 | LLSPASPKRRRCAPL |
Function
Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:34711951). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (PubMed:34711951). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity). Also plays a role in facilitating interdigital tissue regression during limb development (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0017053 | transcription repressor complex |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Biological Process | GO:0002250 | adaptive immune response |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0042742 | defense response to bacterium |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0009792 | embryo development ending in birth or egg hatching |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0071630 | nuclear protein quality control by the ubiquitin-proteasome system |
| Biological Process | GO:0002821 | positive regulation of adaptive immune response |
| Biological Process | GO:0050871 | positive regulation of B cell activation |
| Biological Process | GO:0045089 | positive regulation of innate immune response |
| Biological Process | GO:0032755 | positive regulation of interleukin-6 production |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0031144 | proteasome localization |
| Biological Process | GO:0006606 | protein import into nucleus |
| Biological Process | GO:0051147 | regulation of muscle cell differentiation |
Reference
PMID: N/A