Search Results
Overview
| Uniprot ID | Q53H82 |
|---|---|
| Protein Name | Endoribonuclease LACTB2 |
| Gene Name | LACTB2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 191 | LKELLKIKADIIYPG |
| 247 | ELVKIIYKNTPENLH |
| 266 | HNLLLHLKKLEKEGK |
Function
Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability
Protein Sequence
10
MAAVLQRVER
20
LSNRVVRVLG
30
CNPGPMTLQG
40
TNTYLVGTGP
50
RRILIDTGEP
60
AIPEYISCLK
70
QALTEFNTAI
80
QEIVVTHWHR
90
DHSGGIGDIC
100
KSINNDTTYC
110
IKKLPRNPQR
120
EEIIGNGEQQ
130
YVYLKDGDVI
140
KTEGATLRVL
150
YTPGHTDDHM
160
ALLLEEENAI
170
FSGDCILGEG
180
TTVFEDLYDY
190
MNSLKELLKI
200
KADIIYPGHG
210
PVIHNAEAKI
220
QQYISHRNIR
230
EQQILTLFRE
240
NFEKSFTVME
250
LVKIIYKNTP
260
ENLHEMAKHN
270
LLLHLKKLEK
280
EGKIFSNTDP
DKKWKAHL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0004521 | RNA endonuclease activity |
| Molecular Function | GO:0003727 | single-stranded RNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.