Search Results
Overview
| Uniprot ID | Q53HL2 |
|---|---|
| Protein Name | Borealin |
| Gene Name | CDCA8 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 109 | EAIQTPLKSAKTRKV |
| 198 | RFDSRVFKTPGLRTP |
Function
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment
Protein Sequence
10
MAPRKGSSRV
20
AKTNSLRRRK
30
LASFLKDFDR
40
EVEIRIKQIE
50
SDRQNLLKEV
60
DNLYNIEILR
70
LPKALREMNW
80
LDYFALGGNK
90
QALEEAATAD
100
LDITEINKLT
110
AEAIQTPLKS
120
AKTRKVIQVD
130
EMIVEEEEEE
140
ENERKNLQTA
150
RVKRCPPSKK
160
RTQSIQGKGK
170
GKRSSRANTV
180
TPAVGRLEVS
190
MVKPTPGLTP
200
RFDSRVFKTP
210
GLRTPAAGER
220
IYNISGNGSP
230
LADSKEIFLT
240
VPVGGGESLR
250
LLASDLQRHS
260
IAQLDPEALG
270
NIKKLSNRLA
280
QICSSIRTHK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0010369 | chromocenter |
| Cellular Component | GO:0032133 | chromosome passenger complex |
| Cellular Component | GO:0000775 | chromosome, centromeric region |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0051233 | spindle midzone |
| Biological Process | GO:0051276 | chromosome organization |
| Biological Process | GO:0000278 | mitotic cell cycle |
| Biological Process | GO:0000281 | mitotic cytokinesis |
| Biological Process | GO:0007080 | mitotic metaphase chromosome alignment |
| Biological Process | GO:0000070 | mitotic sister chromatid segregation |
| Biological Process | GO:0090307 | mitotic spindle assembly |
| Biological Process | GO:0051256 | mitotic spindle midzone assembly |
| Biological Process | GO:1902425 | positive regulation of attachment of mitotic spindle microtubules to kinetochore |
| Biological Process | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint |
| Biological Process | GO:1903490 | positive regulation of mitotic cytokinesis |
| Biological Process | GO:1901970 | positive regulation of mitotic sister chromatid separation |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.