Search Results

Overview

Uniprot ID	Q562E7
Protein Name	WD repeat-containing protein 81
Gene Name	WDR81
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1134	EGGAPVDKSSLRSGD
705	SRPGRRNKAAGADPG

Function

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity)

Protein Sequence

10 MAQGSGGREG 20 ALRTPAGGWH 30 SPPSPDMQEL 40 LRSVERDLSI 50 DPRQLAPAPG 60 GTHVVALVPA 70 RWLASLRDRR 80 LPLGPCPRAE 90 GLGEAEVRTL 100 LQRSVQRLPA 110 GWTRVEVHGL 120 RKRRLSYPLG 130 GGLPFEDGSC 140 GPETLTRFMQ 150 EVAAQNYRNL 160 WRHAYHTYGQ 170 PYSHSPAPSA 180 VPALDSVRQA 190 LQRVYGCSFL 200 PVGETTQCPS 210 YAREGPCPPR 220 GSPACPSLLR 230 AEALLESPEM 240 LYVVHPYVQF 250 SLHDVVTFSP 260 AKLTNSQAKV 270 LFILFRVLRA 280 MDACHRQGLA 290 CGALSLYHIA 300 VDEKLCSELR 310 LDLSAYERPE 320 EDENEEAPVA 330 RDEAGIVSQE 340 EQGGQPGQPT 350 GQEELRSLVL 360 DWVHGRISNF 370 HYLMQLNRLA 380 GRRQGDPNYH 390 PVLPWVVDFT 400 TPHGRFRDLR 410 KSKFRLNKGD 420 KQLDFTYEMT 430 RQAFVAGGAG 440 GGEPPHVPHH 450 ISDVLSDITY 460 YVYKARRTPR 470 SVLCGHVRAQ 480 WEPHEYPASM 490 ERMQNWTPDE 500 CIPEFYTDPS 510 IFRSIHPDMP 520 DLDVPAWCSS 530 SQEFVAAHRA 540 LLESREVSRD 550 LHHWIDLTFG 560 YKLQGKEAVK 570 EKNVCLHLVD 580 AHTHLASYGV 590 VQLFDQPHPQ 600 RLAGAPALAP 610 EPPLIPKLLV 620 QTIQETTGRE 630 DFTENPGQLP 640 NGVGRPVLEA 650 TPCEASWTRD 660 RPVAGEDDLE 670 QATEALDSIS 680 LAGKAGDQLG 690 SSSQASPGLL 700 SFSVASASRP 710 GRRNKAAGAD 720 PGEGEEGRIL 730 LPEGFNPMQA 740 LEELEKTGNF 750 LAKGLGGLLE 760 VPEQPRVQPA 770 VPLQCLLHRD 780 MQALGVLLAE 790 MVFATRVRTL 800 QPDAPLWVRF 810 QAVRGLCTRH 820 PKEVPVSLQP 830 VLDTLLQMSG 840 PEVPMGAERG 850 KLDQLFEYRP 860 VSQGLPPPCP 870 SQLLSPFSSV 880 VPFPPYFPAL 890 HRFILLYQAR 900 RVEDEAQGRE 910 LVFALWQQLG 920 AVLKDITPEG 930 LEILLPFVLS 940 LMSEEHTAVY 950 TAWYLFEPVA 960 KALGPKNANK 970 YLLKPLIGAY 980 ESPCQLHGRF 990 YLYTDCFVAQ 1000 LMVRLGLQAF 1010 LTHLLPHVLQ 1020 VLAGAEASQE 1030 ESKDLAGAAE 1040 EEESGLPGAG 1050 PGSCAFGEEI 1060 PMDGEPPASS 1070 GLGLPDYTSG 1080 VSFHDQADLP 1090 ETEDFQAGLY 1100 VTESPQPQEA 1110 EAVSLGRLSD 1120 KSSTSETSLG 1130 EERAPDEGGA 1140 PVDKSSLRSG 1150 DSSQDLKQSE 1160 GSEEEEEEED 1170 SCVVLEEEEG 1180 EQEEVTGASE 1190 LTLSDTVLSM 1200 ETVVAGGSGG 1210 DGEEEEEALP 1220 EQSEGKEQKI 1230 LLDTACKMVR 1240 WLSAKLGPTV 1250 ASRHVARNLL 1260 RLLTSCYVGP 1270 TRQQFTVSSG 1280 ESPPLSAGNI 1290 YQKRPVLGDI 1300 VSGPVLSCLL 1310 HIARLYGEPV 1320 LTYQYLPYIS 1330 YLVAPGSASG 1340 PSRLNSRKEA 1350 GLLAAVTLTQ 1360 KIIVYLSDTT 1370 LMDILPRISH 1380 EVLLPVLSFL 1390 TSLVTGFPSG 1400 AQARTILCVK 1410 TISLIALICL 1420 RIGQEMVQQH 1430 LSEPVATFFQ 1440 VFSQLHELRQ 1450 QDLKLDPAGR 1460 GEGQLPQVVF 1470 SDGQQRPVDP 1480 ALLDELQKVF 1490 TLEMAYTIYV 1500 PFSCLLGDII 1510 RKIIPNHELV 1520 GELAALYLES 1530 ISPSSRNPAS 1540 VEPTMPGTGP 1550 EWDPHGGGCP 1560 QDDGHSGTFG 1570 SVLVGNRIQI 1580 PNDSRPENPG 1590 PLGPISGVGG 1600 GGLGSGSDDN 1610 ALKQELPRSV 1620 HGLSGNWLAY 1630 WQYEIGVSQQ 1640 DAHFHFHQIR 1650 LQSFPGHSGA 1660 VKCVAPLSSE 1670 DFFLSGSKDR 1680 TVRLWPLYNY 1690 GDGTSETAPR 1700 LVYTQHRKSV 1710 FFVGQLEAPQ 1720 HVVSCDGAVH 1730 VWDPFTGKTL 1740 RTVEPLDSRV 1750 PLTAVAVMPA 1760 PHTSITMASS 1770 DSTLRFVDCR 1780 KPGLQHEFRL 1790 GGGLNPGLVR 1800 ALAISPSGRS 1810 VVAGFSSGFM 1820 VLLDTRTGLV 1830 LRGWPAHEGD 1840 ILQIKAVEGS 1850 VLVSSSSDHS 1860 LTVWKELEQK 1870 PTHHYKSASD 1880 PIHTFDLYGS 1890 EVVTGTVSNK 1900 IGVCSLLEPP 1910 SQATTKLSSE 1920 NFRGTLTSLA 1930 LLPTKRHLLL 1940 GSDNGVIRLL A

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000421	autophagosome membrane
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0031901	early endosome membrane
Cellular Component	GO:0010008	endosome membrane
Cellular Component	GO:0031902	late endosome membrane
Cellular Component	GO:0005765	lysosomal membrane
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding
Molecular Function	GO:0141039	phosphatidylinositol 3-kinase inhibitor activity
Molecular Function	GO:0035014	phosphatidylinositol 3-kinase regulator activity
Biological Process	GO:0035973	aggrephagy
Biological Process	GO:0045022	early endosome to late endosome transport
Biological Process	GO:0007005	mitochondrion organization
Biological Process	GO:0050821	protein stabilization
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.