Search Results
Overview
| Uniprot ID | Q566R0 |
|---|---|
| Protein Name | Acyl-coenzyme A thioesterase THEM4 |
| Gene Name | Them4 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 92 | FVDSKFKKEEQMSKA |
| 98 | KKEEQMSKAQQFTRS |
Function
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism (By similarity). Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity (By similarity)
Protein Sequence
10
MLRSCAMRLR
20
TLGATPARRP
30
EATRRLFSSE
40
EVVCKDYALP
50
NPSWTKDLRL
60
LFDQFMKKCE
70
DGSWKRLPSY
80
RQNPPQALQE
90
FQTHFVDSKF
100
KKEEQMSKAQ
110
QFTRSLEEGL
120
GFEYAMFYNK
130
AEKRIVCLFQ
140
GGLHLQGMPG
150
FVHGGAIATI
160
IDITAGMCAF
170
SEGIVMTANL
180
NIDYKKPIPL
190
LSVVVVNSQL
200
QKIEGRKLFV
210
SCTIQSTDEK
220
TLHTQATALF
230
IKLDPDKPLT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005758 | mitochondrial intermembrane space |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0032587 | ruffle membrane |
| Molecular Function | GO:0052816 | long-chain fatty acyl-CoA hydrolase activity |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0051898 | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:1902108 | regulation of mitochondrial membrane permeability involved in apoptotic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.